Evidence map›Paper›PMID 25893192›Full record

ArticleBioMed research international2015

Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the neurodegeneration process in the pathogenesis of primary open angle glaucoma.

Alicja Nowak, Ireneusz Majsterek, Karolina Przybyłowska-Sygut, Dariusz Pytel, Katarzyna Szymanek, Jerzy Szaflik, Jacek P Szaflik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Normal-tension glaucoma: Pathogenesis and genetics.Experimental and therapeutic medicine · 2019
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Glaucomagenesis following ionizing radiation exposure.Mutation research. Reviews in mutation research
    Review
  13. Exercise as Gene Therapy: BDNF and DNA Damage Repair.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alicja NowakDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Hallera 1 Square, 90-647 Lodz, Poland.
Ireneusz MajsterekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Hallera 1 Square, 90-647 Lodz, Poland.
Karolina Przybyłowska-SygutDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Hallera 1 Square, 90-647 Lodz, Poland.
Dariusz PytelThe Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Katarzyna SzymanekDepartment of Ophthalmology, Medical University of Warsaw, Sierakowskiego 13 street, 03-709 Warsaw, Poland ; SPKSO Ophthalmic Hospital, Sierakowskiego 13 street, 03-709 Warsaw, Poland.
Jerzy SzaflikDepartment of Ophthalmology, Medical University of Warsaw, Sierakowskiego 13 street, 03-709 Warsaw, Poland ; SPKSO Ophthalmic Hospital, Sierakowskiego 13 street, 03-709 Warsaw, Poland.
Jacek P SzaflikDepartment of Ophthalmology, Medical University of Warsaw, Sierakowskiego 13 street, 03-709 Warsaw, Poland ; SPKSO Ophthalmic Hospital, Sierakowskiego 13 street, 03-709 Warsaw, Poland.
Medical University of Lodz · PLMedical University of Warsaw · PLUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is characterized by optic neuropathy of the RGC or retinal nerve fiber. The aim of this study was to evaluate a relationship between the neurodegenerative genes' polymorphisms of the APOE (rs449647), BDNF (rs2030324), GRIN2B (rs3764028), and HSP70-1 (rs1043618) and the occurrence risk of POAG and to investigate its effect on allele-specific gene expression. Genomic DNA was extracted from peripheral blood. Analysis of the genes' polymorphisms was performed using PCR-RFLP. The level of mRNA expression was determined by QRT-PCR. We showed a statistically significant association of BDNF and APOE genes' polymorphisms with a risk of POAG occurrence. There was a statistically significant association of the rs2030324 polymorphism with progression of POAG based on cup disc ratio value and rs1043618 polymorphism based on nerve fiber index and rim area. Furthermore, we found that mean HSP70-1 mRNA expression was significantly lower in the case of individuals with the G/G genotype than in the case of minor allele carriers, that is, G/C and C/C. We also found that BDNF and HSP70-1 expression level are associated with the progression of POAG based on rim area value. In conclusion, our results suggest that BDNF, APOE, and HSP70-1 genes might be associated with a risk of POAG occurrence in the Polish population.

Indexed as

AgedAllelesApolipoproteins EBrain-Derived Neurotrophic FactorCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeGlaucoma, Open-AngleHSP70 Heat-Shock ProteinsHumansMaleMiddle AgedNeurodegenerative DiseasesPolandPolymorphism, Restriction Fragment LengthApolipoproteins EBDNF protein, humanBrain-Derived Neurotrophic FactorHSP70 Heat-Shock ProteinsHspa14 protein, humanNR2B NMDA receptorReceptors, N-Methyl-D-Aspartate

Identifiers

PMID25893192
PMCPMC4393917
OpenAlexW2078140110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.