ReviewComputational and structural biotechnology journal2015
Genome mining: Prediction of lipopeptides and polyketides from Bacillus and related Firmicutes.
Review in Computational and structural biotechnology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 86 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Safety and Efficacy of Oral-Spray Bacillus Probiotic (LiveSpo® Smile CARE) in the Prevention and Adjunctive Treatment of Dental Caries in Children
Evaluating Safety and Efficacy of Oral-Spray Bacillus Spore Probiotics (LiveSpo Smile CARE) in Preventing and Supporting the Treatment of Periodontal Diseases in Elderly in Hanoi
Who cites it
86 citing papers in PubMed.
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- A Promising Strain for Wheat Growth Promotion and Antifungal Activity Against Fungal Phytopathogens:Microorganisms · 2026Article
- Fengycin deficiency in Bacillus subtilis Pfen-1 increases antagonism and reveals a non-functional role against Sclerotinia sclerotiorum.Scientific reports · 2026Article
- Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associatedmSystems · 2026Article
- Genomic insights into the broad-spectrum antifungal activity of a novel Paenibacillus polymyxa strain X-11.BMC microbiology · 2026Article
- Biofertilizer induces soil disease suppression by activating pathogen suppressive protist taxa.NPJ biofilms and microbiomes · 2026Article
- Genomic sequencing of vineyard-isolatedFrontiers in microbiology · 2026Article
- Investigating Bacillus amyloliquefaciens VFS2 for Vicia faba-fusarium wilt biocontrol and plant growth promotion under osmotic stress.Pest management science · 2025Article
- Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis.Microbial cell factories · 2025Article
- Comparative Genomic Analysis of Three Paenibacillus polymyxa Strains Isolated from Termitarium and Identification of Novel Biosynthetic Gene Clusters.Current microbiology · 2025Article
- Functional and genomic analyses of plant growth promoting traits in Priestia aryabhattai and Paenibacillus sp. isolates from tomato rhizosphere.Scientific reports · 2025Article
- Article
- Prospection for potential new non-ribosomal peptide gene clusters inFrontiers in microbiology · 2025Article
- Social wasp-associated Tsukamurella sp. strains showed promising biosynthetic and bioactive potential for discovery of novel compounds.Scientific reports · 2024Article
- Mining biosynthetic gene clusters in Paenibacillus genomes to discover novel antibiotics.BMC microbiology · 2024Article
- Characterization ofFrontiers in plant science · 2024Article
- Inhibitory effects of Bacillus velezensis ID-A01 supernatant against Streptococcus mutans.BMC microbiology · 2023Article
- Natural Products and Pharmacological Properties of Symbiotic Bacillota (Firmicutes) of Marine Macroalgae.Marine drugs · 2023Review
- Antimicrobial peptides from Bacillus spp. and strategies to enhance their yield.Applied microbiology and biotechnology · 2023Review
- Secretome of Paenibacillus sp. S-12 provides an insight about its survival and possible pathogenicity.Folia microbiologica · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus and related genera in the Bacillales within the Firmicutes harbor a variety of secondary metabolite gene clusters encoding polyketide synthases and non-ribosomal peptide synthetases responsible for remarkable diverse number of polyketides (PKs) and lipopeptides (LPs). These compounds may be utilized for medical and agricultural applications. Here, we summarize the knowledge on structural diversity and underlying gene clusters of LPs and PKs in the Bacillales. Moreover, we evaluate by using published prediction tools the potential metabolic capacity of these bacteria to produce type I PKs or LPs. The huge sequence repository of bacterial genomes and metagenomes provides the basis for such genome-mining to reveal the potential for novel structurally diverse secondary metabolites. The otherwise cumbersome task to isolate often unstable PKs and deduce their structure can be streamlined. Using web based prediction tools, we identified here several novel clusters of PKs and LPs from genomes deposited in the database. Our analysis suggests that a substantial fraction of predicted LPs and type I PKs are uncharacterized, and their functions remain to be studied. Known and predicted LPs and PKs occurred in the majority of the plant associated genera, predominantly in Bacillus and Paenibacillus. Surprisingly, many genera from other environments contain no or few of such compounds indicating the role of these secondary metabolites in plant-associated niches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.