Evidence map›Paper›PMID 25893016›Full record

ArticleThe open biomedical engineering journal2015

A review paper on biomimetic calcium phosphate coatings.

X Lin, K de Groot, D Wang, Q Hu, D Wismeijer, Y Liu

Abstract read
In one paragraph

Article in The open biomedical engineering journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  7. Review
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  14. Dental Implant Bioactive Surface Modifiers: An Update.Journal of International Society of Preventive & Community Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

X LinDepartment of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands ; Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China.
K de GrootDepartment of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
D WangDepartment of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
Q HuDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China.
D WismeijerDepartment of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
Y LiuDepartment of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.

Indexed as

Animal modelbiomimeticcalcium phosphate coatingclinical applicationdrug deliveryhydroxyapatiteosseoconductionosseoinductionpre-clinical study

Identifiers

PMID25893016
PMCPMC4391212

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.