ArticleThe open biomedical engineering journal2015
Bioactive titanate layers formed on titanium and its alloys by simple chemical and heat treatments.
Article in The open biomedical engineering journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A novel strategy for secretory leukocyte protease inhibitor (SLPI) immobilization on alkaline-etched titanium via a plasma-polymerized interlayer and covalent coupling to enhance osteoblast activity.Scientific reports · 2026Article
- Article
- Controlling Sodium Titanate Crystal Size to Improve Wettability and Early Osseointegration of Titanium Implants: Insights from an Animal Model.Journal of functional biomaterials · 2025Article
- Antibacterial Properties and Biocompatibility of Multicomponent Titanium Oxides: A Review.Materials (Basel, Switzerland) · 2024Review
- Graphene oxide/ε-poly-L-lysine self-assembled functionalized coatings improve the biocompatibility and antibacterial properties of titanium implants.Frontiers in bioengineering and biotechnology · 2024Article
- Bioactive and antimicrobial macro-/micro-nanoporous selective laser melted Ti-6Al-4V alloy for biomedical applications.Heliyon · 2022Article
- Pre-Clinical Models in Implant Dentistry: Past, Present, Future.Biomedicines · 2021Review
- Bioactivation Treatment with Mixed Acid and Heat on Titanium Implants Fabricated by Selective Laser Melting Enhances Preosteoblast Cell Differentiation.Nanomaterials (Basel, Switzerland) · 2021Article
- Hydroxyapatite Formation on Coated Titanium Implants Submerged in Simulated Body Fluid.Materials (Basel, Switzerland) · 2020Article
- The optimized preparation of HA/L-TiORegenerative biomaterials · 2020Article
- Phase-Selective and Localized TiOACS omega · 2020Article
- Effects of negatively and positively charged Ti metal surfaces on ceramic coating adhesion and cell response.Journal of materials science. Materials in medicine · 2017Article
- Surface thermal oxidation on titanium implants to enhance osteogenic activity and in vivo osseointegration.Scientific reports · 2016Article
- In vivo study of the early bone-bonding ability of Ti meshes formed with calcium titanate via chemical treatments.Journal of materials science. Materials in medicine · 2015Article
- Effect of anodization and alkali-heat treatment on the bioactivity of titanium implant material (an in vitro study).Journal of International Society of Preventive & Community DentistryArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To reveal general principles for obtaining bone-bonding bioactive metallic titanium, Ti metal was heat-treated after exposure to a solution with different pH. The material formed an apatite layer at its surface in simulated body fluid when heat-treated after exposure to a strong acid or alkali solution, because it formed a positively charged titanium oxide and negatively charged sodium titanate film on its surface, respectively. Such treated these Ti metals tightly bonded to living bone. Porous Ti metal heat-treated after exposure to an acidic solution exhibited not only osteoconductive, but also osteoinductive behavior. Porous Ti metal exposed to an alkaline solution also exhibits osteoconductivity as well as osteoinductivity, if it was subsequently subjected to acid and heat treatments. These acid and heat treatments were not effective for most Ti-based alloys. However, even those alloys exhibited apatite formation when they were subjected to acid and heat treatment after a NaOH treatment, since the alloying elements were removed from the surface by the latter. The NaOH and heat treatments were also not effective for Ti-Zr-Nb-Ta alloys. These alloys displayed apatite formation when subjected to CaCl2 treatment after NaOH treatment, forming Ca-deficient calcium titanate at their surfaces after subsequent heat and hot water treatments. The bioactive Ti metal subjected to NaOH and heat treatments has been clinically used as an artificial hip joint material in Japan since 2007. A porous Ti metal subjected to NaOH, HCl and heat treatments has successfully undergone clinical trials as a spinal fusion device.
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