ArticleThe Malaysian journal of medical sciences : MJMS
Quercus infectoria Gall Extract Enhanced the Proliferation and Activity of Human Fetal Osteoblast Cell Line (hFOB 1.19).
Article in The Malaysian journal of medical sciences : MJMS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Internal gelation-based alginate hydrogel films incorporating Quercus infectoria gall extract for multifunctional wound dressing applications.Scientific reports · 2026Article
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- Removal ofJournal of microbiology and biotechnology · 2021Article
- Medicinal Uses, Phytochemistry, and Pharmacological Activities ofEvidence-based complementary and alternative medicine : eCAM · 2020Review
- The Role of Semipurified Fractions Isolated fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Gallnuts: A Potential Treasure in Anticancer Drug Discovery.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Dexmedetomidine attenuates HJournal of dental anesthesia and pain medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study investigated the effects of Quercus infectoria (QI) gall extract on the proliferation, alkaline phosphatase (ALP), osteocalcin, and the morphology of a human fetal osteoblast cell line (hFOB 1.19).
methodsThe cells were cultured in Dulbecco's modified eagle medium F12 supplemented with a 10% fetal bovine serum, a 1% penicillin/streptomycin and were treated with QI at various concentrations (0.1 to 99.0 μg/mL) for 72 hours. The levels of ALP and osteocalcin were measured at day 1, 3, 7, 10, and 14 and were compared among the negative control, pamidronate and QI groups.
resultsThe median effective concentration (EC50) of hFOB 1.19 treated with QI was 10.30 μg/mL. This concentration was more effective compared to the control drug, pamidronate (EC50 at 16.09 μg/mL). The ALP and osteocalcin levels of hFOB 1.19 treated with QI from day 7 and onwards were significantly increased in a time and concentration-dependent manner. Interestingly, from day 7 until day 14, the ALP and osteocalcin levels were highest in the cells treated with QI compared to the other two groups. The morphology of cells treated with QI was uniformly elongated, higher in number and over-confluent.
conclusionAfter treatment with QI, cell proliferation enhanced and ALP and osteocalcin levels increased.
Indexed as
Identifiers
25892946PMC4390770What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.