Evidence map›Paper›PMID 25892860›Full record

ReviewWorld journal of gastroenterology2015

Point-of-care testing in the diagnosis of gastrointestinal cancers: current technology and future directions.

Jeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Faecal Occult Blood Point-of-Care Tests.Journal of gastrointestinal cancer · 2018
    Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeremy R HuddyJeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna, Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, South Wharf Road, W2 1NY London, United Kingdom.
Melody Z NiJeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna, Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, South Wharf Road, W2 1NY London, United Kingdom.
Sheraz R MarkarJeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna, Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, South Wharf Road, W2 1NY London, United Kingdom.
George B HannaJeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna, Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, South Wharf Road, W2 1NY London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Point-of-care (POC) tests enable rapid results and are well established in medical practice. Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways. This review aims to identify current and new technologies for the POC diagnosis of gastrointestinal cancer. A structured search of the Embase and Medline databases was performed. Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included. Studies recovered were heterogeneous and therefore results are presented as a narrative review. Six diagnostic methods were identified (fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis). Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%. The others are at a range of development and clinical application. POC devices have a proven role in the diagnosis of gastrointestinal cancer. Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow. New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival.

Indexed as

Biomarkers, TumorDNA Mutational AnalysisEarly Detection of CancerForecastingGastrointestinal NeoplasmsHumansMetabolomicsMutationNeoplasm StagingOccult BloodPoint-of-Care SystemsPoint-of-Care TestingPredictive Value of TestsReproducibility of ResultsBiomarkers, TumorCancer-diagnosisColorectal cancerDiagnostic testsEsophageal cancerGastric cancer

Identifiers

PMID25892860
PMCPMC4394071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.