ArticleJournal of food science and technology2015
Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum.
Article in Journal of food science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associated Targets of the Antioxidant Cardioprotection ofBioMed research international · 2020Pooled it
- An Amazonian Ganoderma isolate as a source of antioxidant proteins: Influence of submerged fermentation conditions on mycelial architecture and bioactivity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Impact of Submerged Fermentation Parameters on Proteins Extracted fromMicroorganisms · 2026Article
- Ganodermataceae-current status, research, and development in Lower Mekong Basin.Frontiers in cellular and infection microbiology · 2025Review
- Bioactive Peptides and Other Immunomodulators of Mushroom Origin.Biomedicines · 2024Review
- Review
- Natural Bio-Compounds fromAntioxidants (Basel, Switzerland) · 2023Review
- Bioactive Peptides from Edible Mushrooms-The Preparation, Mechanisms, Structure-Activity Relationships and Prospects.Foods (Basel, Switzerland) · 2023Review
- Nutritional Profile and Health Benefits ofFoods (Basel, Switzerland) · 2022Review
- Article
- Effect ofAdvanced biomedical research · 2018Article
- Culture broth ofJournal of food science and technology · 2017Article
- Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms.BioMed research international · 2017Review
- Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial and DNA protective activities. It was found that the half maximal inhibitory concentration (IC50) of the mycelia protein and fruiting bodies protein extracts against 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical (ABTS(•+)) were 2.47 ± 0.01 and 2.77 ± 0.11 μg protein/ml and against 2,2-diphenylpicrylhydrazyl radical (DPPH(•)) were 2.5 ± 0.01 and 3.42 ± 0.01 μg protein/ml, respectively. The ferric reducing-antioxidant power (FRAP) values of those samples were 1.73 ± 0.01 and 2.62 ± 0.01 μmole trolox/μg protein respectively. Protein hydrolysates prepared by pronase exhibited a weaker antioxidant activity. Both crude proteins showed antibacterial activity, whereas only the mycelia protein extract could protect DNA damage by hydroxyl ((•)OH) radicals. This protein extract was partial purified by Diethyl amino ethyl (DEAE)-Sepharose column and Sulfopropyl (SP)-Sepharose column, obtained major protein with molecular weight about 45 kilo Dalton (kDa). In conclusion, G. lucidum protein extracts have promise potential for applications as antioxidant and antibacterial agents.
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