ReviewThe American journal of pathology2015
Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions.
Review in The American journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
254 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Treatment of brucellosis in pregnant women: a systematic review and analysis of current gaps and future perspectives.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Pooled it
- Comprehensive Meta-Analysis of Brucellosis in Wild and Domestic Birds: Unraveling the Complex Interplay of Transmission and Ecology (1970-2024).Current microbiology · 2025Pooled it
- Global Comprehensive Literature Review and Meta-Analysis of Brucella spp. in Swine Based on Publications From 2000 to 2020.Frontiers in veterinary science · 2021Pooled it
- Brucellosis in food-producing animals in Mosul, Iraq: A systematic review and meta-analysis.PloS one · 2020Pooled it
- HOMEBRED: A unified CRISPR platform for field-ready shadowing of infectious agents and oncogenic mutations.iScience · 2026Article
- Article
- Effect of Brucella effector protein BtpB regulating apoptosis by targeting host protein YWHAZ.Veterinary research · 2026Article
- Review
- Ability ofMicroorganisms · 2026Article
- CALLY Index and Inflammatory Parameters for Predicting Focal Involvement in Human Brucellosis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- A genome-wide CRISPR screen defines host determinants of earlyInfection and immunity · 2026Article
- Article
- Brucellosis in the One Health Context: Gaps in Diagnosis, Control, and Global Epidemiology.Journal of epidemiology and global health · 2026Review
- Brucella outer membrane protein 16 induces trophoblast pyroptosis via rewiring IL-6 trans-signaling and caspase-3/GSDME axis.PLoS neglected tropical diseases · 2026Article
- Clinical and laboratory characteristics of human brucellosis and predictors of focal involvement: a retrospective cohort study from Türkiye.BMC infectious diseases · 2026Observational
- Clinical, Microbiological, and Hematological Characteristics of Pediatric Brucellosis in Saudi Arabia: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Development and Preliminary Evaluation of an OMP16-Targeting Trivalent Nanobody-HRP-Based cELISA for Serological Detection of Bovine Brucellosis.Animals : an open access journal from MDPI · 2026Article
- Shifting risk profiles in the systemic-to-focal transition of brucellosis: a multicenter analysis of spondyloarthritis development.BMC infectious diseases · 2026Article
- A novel duplex TaqMan qPCR assay for rapid differential diagnosis and co-infection screening of Orf virus and Brucella spp. in goats.Veterinary research communications · 2026Article
- Bacterial Granulomatous Lung Diseases: Radiological Findings and Differential Diagnosis.Infectious disease reports · 2026Review
194 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This review of Brucella-host interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limits exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion system-dependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.