ArticleScientific reports2015
Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Human fecal transplantation from stunted children promotes metabolic dysfunction in mice fed with a high-fat and high-fructose corn syrup diet.Gut microbes · 2026Article
- Prefrontal Cortex Dysregulation of Amino Acid-Glucose Homeostasis Links High-Fat and/or High-Fructose Intake to Cognitive Deficits in Male Mice.Neurochemical research · 2026Article
- The impact of housing and high-fructose diet on behavior and cardiovascular response to eucalyptus wildfire smoke in WKY rats.Journal of toxicology and environmental health. Part A · 2026Article
- Effect of Administration of Selenium Nanoparticles Synthesized Using Onion Extract on Biochemical and Inflammatory Parameters in Mice Fed with High-Fructose Diet: In Vivo and In Silico Analysis.Biological trace element research · 2024Article
- Review
- Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.European journal of clinical nutrition · 2022Review
- Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance.Cell metabolism · 2022Article
- Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.Nature metabolism · 2021Article
- Sucrose-Sweetened Drinks Reduce the Physical Performance and Increase the Cardiovascular Risk in Physically Active Males.Journal of nutrition and metabolism · 2021Article
- Review
- Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice.Neurochemical research · 2020Article
- Metabolic effects of the dietary monosaccharides fructose, fructose-glucose, or glucose in mice fed a starch-containing moderate high-fat diet.Physiological reports · 2020Article
- Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.Scientific reports · 2019Article
- [Is There an Effect of Dietary Fructose on Development and Prognosis of Chronic Diseases?]Florence Nightingale hemsirelik dergisi · 2019Article
- Review
- Acute Effects of Glucose and Fructose Administration on the Neural Correlates of Cognitive Functioning in Healthy Subjects: A Pilot Study.Frontiers in psychiatry · 2018Article
- No Adverse Programming by Post-Weaning Dietary Fructose of Body Weight, Adiposity, Glucose Tolerance, or Metabolic Flexibility.Molecular nutrition & food research · 2018Article
- Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis.Lipids in health and disease · 2017Article
- Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence suggests that fructose consumption is associated with weight gain, fat deposition and impaired cognitive function. However it is unclear whether the detrimental effects are caused by fructose itself or by the concurrent increase in overall energy intake. In the present study we examine the impact of a fructose diet relative to an isocaloric glucose diet in the absence of overfeeding, using a mouse model that mimics fructose intake in the top percentile of the USA population (18% energy). Following 77 days of supplementation, changes in body weight (BW), body fat, physical activity, cognitive performance and adult hippocampal neurogenesis were assessed. Despite the fact that no differences in calorie intake were observed between groups, the fructose animals displayed significantly increased BW, liver mass and fat mass in comparison to the glucose group. This was further accompanied by a significant reduction in physical activity in the fructose animals. Conversely, no differences were detected in hippocampal neurogenesis and cognitive/motor performance as measured by object recognition, fear conditioning and rotorod tasks. The present study suggests that fructose per se, in the absence of excess energy intake, increases fat deposition and BW potentially by reducing physical activity, without impacting hippocampal neurogenesis or cognitive function.
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Registered trials
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