Evidence map›Paper›PMID 25892242›Full record

ArticleCell reports2015

Meta-regulation of Arabidopsis auxin responses depends on tRNA maturation.

Johannes Leitner, Katarzyna Retzer, Nenad Malenica, Rasa Bartkeviciute, Doris Lucyshyn, Gunilla Jäger, Barbara Korbei, Anders Byström, Christian Luschnig

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

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  6. AtELP4 a subunit of the Elongator complex inFrontiers in plant science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Johannes LeitnerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Katarzyna RetzerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Nenad MalenicaDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Rasa BartkeviciuteDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Doris LucyshynDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Gunilla JägerDepartment of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Barbara KorbeiDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria.
Anders ByströmDepartment of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Christian LuschnigDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, 1190 Wien, Austria. Electronic address: christian.luschnig@boku.ac.at.
BOKU University · ATUmeå University · SE

Funding

Austrian Science Fund FWF T 477Austrian Science Fund FWF V 382
6 · The paper itself

Abstract

Polar transport of the phytohormone auxin throughout plants shapes morphogenesis and is subject to stringent and specific control. Here, we identify basic cellular activities connected to translational control of gene expression as sufficient to specify auxin-mediated development. Mutants in subunits of Arabidopsis Elongator, a protein complex modulating translational efficiency via maturation of tRNAs, exhibit defects in auxin-controlled developmental processes, associated with reduced abundance of PIN-formed (PIN) auxin transport proteins. Similar anomalies are observed upon interference with tRNA splicing by downregulation of RNA ligase (AtRNL), pointing to a general role of tRNA maturation in auxin signaling. Elongator Protein 6 (ELP6) and AtRNL expression patterns underline an involvement in adjusting PIN protein levels, whereas rescue of mutant defects by auxin indicates rate-limiting activities in auxin-controlled organogenesis. This emphasizes mechanisms in which auxin serves as a bottleneck for plant morphogenesis, translating common cellular activities into defined developmental readouts.

Indexed as

Gene Expression Regulation, DevelopmentalGene Expression Regulation, PlantRNA Processing, Post-TranscriptionalArabidopsisArabidopsis ProteinsIndoleacetic AcidsMembrane Transport ProteinsRNA-Binding ProteinsRNA, TransferArabidopsis ProteinsAT5G57090 protein, ArabidopsisELP6 protein, ArabidopsisIndoleacetic AcidsMembrane Transport ProteinsPIN1 protein, ArabidopsisRNA-Binding ProteinsRNA, Transfer

Identifiers

PMID25892242
PMCPMC4416960
OpenAlexW2048449962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.