ArticleThe European journal of neuroscience2015
Ramping single unit activity in the medial prefrontal cortex and ventral striatum reflects the onset of waiting but not imminent impulsive actions.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Divergent outcomes of delta 9 - tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice.Psychopharmacology · 2025Article
- Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects in male rats.Frontiers in neural circuits · 2025Article
- Role of Orbitofrontal Cortex and Differential Effects of Acute and Chronic Stress on Motor Impulsivity Measured With 1-Choice Serial Reaction Time Test in Male Rats.The international journal of neuropsychopharmacology · 2022Article
- The PRO model accounts for the anterior cingulate cortex role in risky decision-making and monitoring.Cognitive, affective & behavioral neuroscience · 2022Article
- Temporal order judgment of multisensory stimuli in rat and human.Frontiers in behavioral neuroscience · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Traveling waves in the prefrontal cortex during working memory.PLoS computational biology · 2022Article
- A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Impulsive prepotent actions and tics in Tourette disorder underpinned by a common neural network.Molecular psychiatry · 2021Article
- Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum.Nature communications · 2021Article
- Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards.Science advances · 2020Article
- Cerebellar D1DR-expressing neurons modulate the frontal cortex during timing tasks.Neurobiology of learning and memory · 2020Article
- Temporal Learning Among Prefrontal and Striatal Ensembles.Cerebral cortex communications · 2020Article
- Synchronization of Independent Neural Ensembles in Human EEG during Choice Tasks.Behavioral sciences (Basel, Switzerland) · 2019Article
- Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- The Degree of Modulation of Beta Band Activity During Motor Planning Is Related to Trait Impulsivity.Frontiers in integrative neuroscience · 2019Article
- Coordinated Ramping of Dorsal Striatal Pathways preceding Food Approach and Consumption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Rodent Medial Frontal Control of Temporal Processing in the Dorsomedial Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
The medial prefrontal cortex (mPFC) and ventral striatum (VS), including the nucleus accumbens, are key forebrain regions involved in regulating behaviour for future rewards. Dysfunction of these regions can result in impulsivity, characterized by actions that are mistimed and executed without due consideration of their consequences. Here we recorded the activity of single neurons in the mPFC and VS of 16 rats during performance on a five-choice serial reaction time task of sustained visual attention and impulsivity. Impulsive responses were assessed by the number of premature responses made before target stimuli were presented. We found that the majority of cells signalled trial outcome after an action was made (both rewarded and unrewarded). Positive and negative ramping activity was a feature of population activity in the mPFC and VS (49.5 and 50.4% of cells, respectively). This delay-related activity increased at the same rate and reached the same maximum (or minimum) for trials terminated by either correct or premature responses. However, on premature trials, the ramping activity started earlier and coincided with shorter latencies to begin waiting. For all trial types the pattern of ramping activity was unchanged when the pre-stimulus delay period was made variable. Thus, premature responses may result from a failure in the timing of the initiation of a waiting process, combined with a reduced reliance on external sensory cues, rather than a primary failure in delay activity. Our findings further show that the neural locus of this aberrant timing signal may emanate from structures outside the mPFC and VS.
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