ArticleGeneral hospital psychiatry
Psychiatric comorbidity in depressed HIV-infected individuals: common and clinically consequential.
Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Prevalence of depression or depressive symptoms among people living with HIV/AIDS in China: a systematic review and meta-analysis.BMC psychiatry · 2018Pooled it
- Does Problematic Substance Use Moderate Efficacy of Cognitive Behavioral Therapy for Adherence and Depression in HIV?AIDS and behavior · 2023Trial
- Predictors of depression recovery in HIV-infected individuals managed through measurement-based care in infectious disease clinics.Journal of affective disorders · 2016Trial
- The effects of psychological functioning on substance use and treatment outcomes among people with HIV.Scientific reports · 2025Article
- Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling.AIDS and behavior · 2025Article
- Depressive symptoms, stigma and suicidal thoughts among people living with HIV/AIDS attending a Tertiary Hospital in Mwanza, Tanzania: A cross-sectional study.PLOS mental health · 2025Article
- Psychosocial Syndemic Classes and Longitudinal Transition Patterns Among Sexual Minority men Living with or Without HIV in the Multicenter AIDS Cohort Study (MACS).AIDS and behavior · 2023Article
- Validation of the combined Patient Health Questionnaire Anxiety and Depression Scale among people with HIV in Vietnam.International journal of STD & AIDS · 2023Article
- Using Principles of an Adaptation Framework to Adapt a Transdiagnostic Psychotherapy for People With HIV to Improve Mental Health and HIV Treatment Engagement: Focus Groups and Formative Research Study.JMIR formative research · 2023Article
- Long-Term Effectiveness of an Online Self-help Intervention for People with HIV and Depressive Symptoms.AIDS and behavior · 2023Article
- Demonstration project of a lay counselor delivered trans-diagnostic mental health intervention for newly diagnosed HIV patients in Mozambique.AIDS care · 2023Article
- Symptoms of generalized anxiety disorder as a risk factor for substance use among adults living with HIV.AIDS care · 2021Article
- Gut microbiota dysbiosis is associated with worse emotional states in HIV infection.Journal of neurovirology · 2021Article
- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Who is most likely to benefit from a positive psychological intervention? Moderator analyses from a randomized trial in people newly diagnosed with HIV.The journal of positive psychology · 2020Article
- Psychiatric Comorbidity of Unipolar Mood, Anxiety, and Trauma Disorders Prior to HIV Testing and the Effect on Linkage to Care Among HIV-Infected Adults in South Africa.AIDS and behavior · 2019Article
- The Impact of Cumulative Depression Along the HIV Care Continuum in Women Living With HIV During the Era of Universal Antiretroviral Treatment.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- The association between symptoms of generalized anxiety disorder and appointment adherence, overnight hospitalization, and emergency department/urgent care visits among adults living with HIV enrolled in care.Journal of behavioral medicine · 2019Article
- The Depression Treatment Cascade: Disparities by Alcohol Use, Drug Use, and Panic Symptoms Among Patients in Routine HIV Care in the United States.AIDS and behavior · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo report on the prevalence of psychiatric comorbidity and its association with illness severity in depressed HIV patients.
methodsAs part of a multi-site randomized controlled trial of depression treatment for HIV patients, 304 participants meeting criteria for current Major Depressive Disorder (MDD) were assessed for other mood, anxiety and substance use disorders with the Mini-International Neuropsychiatric Interview, a structured psychiatric diagnostic interview. We also assessed baseline adherence, risk, and health measures.
resultsComplicated depressive illness was common. Only 18% of participants experienced MDD with no comorbid psychiatric diagnoses; 49% had comorbid dysthymia, 62% had ≥1 comorbid anxiety disorder, and 28% had a comorbid substance use disorder. Self-reported antiretroviral adherence did not differ by the presence of psychiatric comorbidity. However, psychiatric comorbidity was associated with worse physical health and functioning: compared to those with MDD alone, individuals with ≥1 comorbidity reported more HIV symptoms (5.1 vs. 4.1, P=.01), and worse mental health-related quality of life on the SF-12 (29 vs. 35, P<.01).
conclusionFor HIV patients with MDD, chronic depression and psychiatric comorbidity are strikingly common, and this complexity is associated with greater HIV disease severity and worse quality of life. Appreciating this comorbidity can help clinicians better target those at risk of harder-to-treat HIV disease, and underscores the challenge of treating depression in this population.
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