ArticleNature communications2015
Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Structural basis of metalloid transport by the arsenite efflux pump ArsB.Nature communications · 2026Article
- TheScience advances · 2024Article
- The complete catalog of antimicrobial resistance secondary active transporters inComputational and structural biotechnology journal · 2024Article
- Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA.Nature communications · 2024Article
- Structural and biophysical analysis of aeLife · 2024Article
- The ups and downs of elevator-type di-/tricarboxylate membrane transporters.The FEBS journal · 2022Article
- Review
- A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects.The Biochemical journal · 2021Article
- Structural and Functional Diversity of Resistance-Nodulation-Cell Division Transporters.Chemical reviews · 2021Review
- Article
- Elevator-type mechanisms of membrane transport.Biochemical Society transactions · 2020Review
- Shaping the lipid composition of bacterial membranes for membrane protein production.Microbial cell factories · 2019Article
- Structure and Mechanism of the Divalent Anion/Na⁺ Symporter.International journal of molecular sciences · 2019Review
- Structural models of the NaPi-II sodium-phosphate cotransporters.Pflugers Archiv : European journal of physiology · 2019Review
- Transporters through the looking glass. An insight into the mechanisms of ion-coupled transport and methods that help reveal them.Journal of the Indian Institute of Science · 2018Article
- A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.PLoS pathogens · 2018Article
- Energetic evolution of cellular Transportomes.BMC genomics · 2018Article
- Structure and function of the divalent anion/NaNature communications · 2017Article
- Convergent evolution of the arginine deiminase pathway: the ArcD and ArcE arginine/ornithine exchangers.MicrobiologyOpen · 2017Article
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9 authors.
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Abstract
The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transporters for which no structural information was available. Here we report the crystal structure of A. borkumensis YdaH, revealing a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a plausible pathway for substrate transport. Further analyses also suggest that YdaH could act as an antibiotic efflux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs.
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