Evidence map›Paper›PMID 25892037›Full record

ArticleCell cycle (Georgetown, Tex.)2015

Phosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit.

Min Mo, Alexei Arnaoutov, Mary Dasso

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Linear ubiquitination of p31Cell & bioscience · 2025
    Article
  2. p31Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Review
  4. Role of Polo-like kinase 1 in the regulation of the action of p31Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Min Moa Laboratory of Gene Regulation and Development; National Institute of Child Health and Human Development; National institutes of Health ; Bethesda , MD USA.
Alexei Arnaoutova Laboratory of Gene Regulation and Development; National Institute of Child Health and Human Development; National institutes of Health ; Bethesda , MD USA.
Mary Dassoa Laboratory of Gene Regulation and Development; National Institute of Child Health and Human Development; National institutes of Health ; Bethesda , MD USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USGene Therapy Laboratory · FR

Funding

Mitotic roles of the Nuclear Transport MachineryZIAHD008954 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DASSO, MARY C. · 2015 to 2025
$25.3M
PHS HHS ZIAHD008816
6 · The paper itself

Abstract

p31(comet) plays an important role in spindle assembly checkpoint (SAC) silencing. However, how p31(comet)'s activity is regulated remains unclear. Here we show that the timing of M-phase exit in Xenopus egg extracts (XEEs) depends upon SAC activity, even under conditions that are permissive for spindle assembly. p31(comet) antagonizes the SAC, promoting XEE progression into anaphase after spindles are fully formed. We further show that mitotic p31(comet) phosphorylation by Inhibitor of nuclear factor κ-B kinase-β (IKK-β) enhances this role in SAC silencing. Together, our findings implicate IKK-β in the control of anaphase timing in XEE through p31(comet) activation and SAC downregulation.

Indexed as

AnimalsCell Cycle CheckpointsCell Cycle ProteinsI-kappa B KinaseMad2 ProteinsMitosisM Phase Cell Cycle CheckpointsPhosphorylationSpindle ApparatusXenopusXenopus laevisCell Cycle ProteinsI-kappa B KinaseMad2 Proteins(IKK-β)inhibitor of nuclear factor κ-B kinase-βMad2p31cometSpindle assembly checkpointXenopus

Identifiers

PMID25892037
PMCPMC4825729
OpenAlexW1822429536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.