Evidence map›Paper›PMID 25891862›Full record

ArticleBritish journal of haematology2015

Jumping translocations, a novel finding in chronic lymphocytic leukaemia.

Cecelia R Miller, Deborah Stephens, Amy S Ruppert, Frederick Racke, Andrew McFaddin, Heather Breidenbach, Huey-Jen Lin, Kathy Waller, Tammy Bannerman, Jeffrey A Jones and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Cecelia R MillerDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Deborah StephensDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Amy S RuppertDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Frederick RackeDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Andrew McFaddinComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Heather BreidenbachDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Huey-Jen LinDivision of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Kathy WallerDivision of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Tammy BannermanDivision of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Jeffrey A JonesDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Jennifer A WoyachDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Leslie A AndritsosDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Kami MaddocksDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Weiqiang ZhaoDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Gerard LozanskiDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Joseph M FlynnDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Michael GreverDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
John C ByrdDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Nyla A HeeremaDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
The Ohio State University · US

Funding

SPORE Leukemia Tissue BankP50CA140158 · NCI · OHIO STATE UNIVERSITY · PI BLOOMFIELD, CLARA D · 2009 to 2013
$11.2M
Integrative Training in Biomedical SystemsT32GM068412 · NIGMS · OHIO STATE UNIVERSITY · PI PARVIN, JEFFREY D · 2005 to 2020
$2.4M
NCI NIH HHS P50 CA140158NCI NIH HHS P50-CA140158NIGMS NIH HHS T32 GM068412NIGMS NIH HHS T32GM068412
6 · The paper itself

Abstract

A jumping translocation (JT) is a rare cytogenetic aberration that can occur in haematological malignancy. It involves the translocation of the same fragment of donor chromosome onto two or more recipient chromosomes, typically in different cells. In this study, we describe the first series of chronic lymphocytic leukaemia (CLL) patients with JTs reported to date. Following a review of 878 CLL patient karyotypes, we identified 26 patients (3%) with 97 JTs. The most commonly occurring breakpoint in these translocations was 17p11.2. Loss of TP53 was identified prior to or at the same time as JT in 23 of 26 patients (88%). All patients eventually developed a complex karyotype. All but one patient has required treatment for CLL, with estimated median time to treatment of 11·5 months. This study establishes JTs as a recurrent abnormality found in CLL patients with aggressive disease. JTs contribute to complex karyotypes and, in many cases, are involved in chromosomal rearrangements that result in loss of the tumour suppressor gene TP53.

Indexed as

Translocation, GeneticAdultAgedChromosome BreakpointsChromosomes, Human, Pair 17FemaleGenes, p53HumansKaryotypeKaryotypingLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedNeoplasm Stagingcancer cytogeneticschromosomal rearrangementchronic lymphocytic leukaemiacomplex karyotypeTP53

Identifiers

PMID25891862
PMCPMC4490025
OpenAlexW2073095106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.