ArticleScientific reports2015
Phage-mediated horizontal transfer of a Staphylococcus aureus virulence-associated genomic island.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
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- Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates.Microbiology (Reading, England) · 2025Article
- Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms.Antibiotics (Basel, Switzerland) · 2023Review
- Prevalence and characteristics of foodborne pathogens from slaughtered pig carcasses in Korea.Frontiers in veterinary science · 2023Article
- Toxin-linked mobile genetic elements in major enteric bacterial pathogens.Gut microbiome (Cambridge, England) · 2023Review
- Whole-genome analysis showed the promotion of genetic diversity and coevolution inFrontiers in microbiology · 2023Article
- Prophage-encoded immune evasion factors are critical forCell genomics · 2022Article
- Article
- Clonal Diversity, Antimicrobial Susceptibility and Presence of Genes Encoding Virulence Factors in Staphylococcus aureus Strains Isolated from Cut Wound Infections.Current microbiology · 2022Article
- Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements.Nature communications · 2021Article
- The microbiome-shaping roles of bacteriocins.Nature reviews. Microbiology · 2021Review
- Let Me Upgrade You: Impact of Mobile Genetic Elements on Enterococcal Adaptation and Evolution.Journal of bacteriology · 2021Review
- Clonal diversity and genomic characterization of Panton-valentine Leukocidin (PVL)-positive Staphylococcus aureus in Tehran, Iran.BMC infectious diseases · 2021Article
- Genome Sequencing of a Historic Staphylococcus aureus Collection Reveals New Enterotoxin Genes and Sheds Light on the Evolution and Genomic Organization of This Key Virulence Gene Family.Journal of bacteriology · 2021Article
- Proteomic Characterization of Bacteriophage Peptides from the Mastitis ProducerFoods (Basel, Switzerland) · 2021Article
- Underrated Staphylococcus species and their role in antimicrobial resistance spreading.Genetics and molecular biology · 2020Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Staphylococcus aureus is a major pathogen of humans and animals. The capacity of S. aureus to adapt to different host species and tissue types is strongly influenced by the acquisition of mobile genetic elements encoding determinants involved in niche adaptation. The genomic islands νSaα and νSaβ are found in almost all S. aureus strains and are characterized by extensive variation in virulence gene content. However the basis for the diversity and the mechanism underlying mobilization of the genomic islands between strains are unexplained. Here, we demonstrated that the genomic island, νSaβ, encoding an array of virulence factors including staphylococcal superantigens, proteases, and leukotoxins, in addition to bacteriocins, was transferrable in vitro to human and animal strains of multiple S. aureus clones via a resident prophage. The transfer of the νSaβ appears to have been accomplished by multiple conversions of transducing phage particles carrying overlapping segments of the νSaβ. Our findings solve a long-standing mystery regarding the diversification and spread of the genomic island νSaβ, highlighting the central role of bacteriophages in the pathogenic evolution of S. aureus.
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