ArticleMolecular medicine reports2015
Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats.
Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- [Diabetic retinopathy and risk modification through diet and dietary supplements].Die Ophthalmologie · 2025Review
- Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study.Lipids in health and disease · 2024Article
- Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach.Discover oncology · 2024Article
- Higher betaine is associated with lower incidence of microvascular complications in type 2 diabetes (Zodiac-61).European journal of clinical investigation · 2023Article
- Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine.Experimental neurobiology · 2021Article
- Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021Review
- Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone.Frontiers in pharmacology · 2021Article
- Protective effect of the extremolytes ectoine and hydroxyectoine in a porcine organ culture.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Nutritional and medical food therapies for diabetic retinopathy.Eye and vision (London, England) · 2020Review
- Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features.Biomolecules · 2019Article
- Alterations in System xMolecular neurobiology · 2018Article
- Betaine in Inflammation: Mechanistic Aspects and Applications.Frontiers in immunology · 2018Review
- Effects of Lycium barbarum (goji berry) on dry eye disease in rats.Molecular medicine reports · 2018Article
- Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model.Nutrients · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Diabetic retinopathy is a severe microvascular complication amongst patients with diabetes, and is the primary cause of visual loss through neovascularization. Betaine is one of the components of Fructus Lycii. In the present study, the effects of betaine on the expression levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α in association with the Akt pathway were investigated in the retinas of streptozotocin (STZ)-induced diabetic rats using western blot and immunohistochemical analyses. The results of the present study revealed that the expression levels of VEGF, HIF-1α, and Akt were increased in the retinas of the STZ-induced diabetic rats. Betaine treatment attenuated this increase in VEGF and HIF-1α expression via suppression of diabetes-induced Akt activation in the retinas of the diabetic rats. The results suggested that betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes.
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