ArticleDrug and alcohol dependence2015
Predictors of the nicotine reinforcement threshold, compensation, and elasticity of demand in a rodent model of nicotine reduction policy.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Nicotine Reduction in Cigarettes: Literature Review and Gap Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Pooled it
- Mouth-Level Nicotine Intake Estimates from Discarded Filter Butts to Examine Compensatory Smoking in Low Nicotine Cigarettes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Trial
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination.bioRxiv : the preprint server for biology · 2024Article
- Individual variations in motives for nicotine self-administration in male rats: evidence in support for a precision psychopharmacology.Translational psychiatry · 2024Article
- Magnitude and predictors of elasticity of demand for morphine are similar in male and female rats.Frontiers in behavioral neuroscience · 2024Article
- The relative reinforcing efficacy of nicotine in an adolescent rat model of attention-deficit hyperactivity disorder.Frontiers in psychiatry · 2023Article
- Stimulus functions of nicotine.Advances in pharmacology (San Diego, Calif.) · 2022Article
- The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.Drug and alcohol dependence · 2021Article
- Nicotine reduction does not alter essential value of nicotine or reduce cue-induced reinstatement of nicotine seeking.Drug and alcohol dependence · 2020Article
- Differences in acute reinforcement across reduced nicotine content cigarettes.Psychopharmacology · 2020Article
- Comparison of the Relative Abuse Liability of Electronic Cigarette Aerosol Extracts and Nicotine Alone in Adolescent Rats: A Behavioral Economic Analysis.International journal of environmental research and public health · 2020Article
- Research on Behavioral Discrimination of Nicotine May Inform FDA Policy on Setting a Maximum Nicotine Content in Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Comparison of cigarette, little cigar, and waterpipe tobacco smoke condensate and e-cigarette aerosol condensate in a self-administration model.Behavioural brain research · 2019Article
- Economic demand analysis of within-session dose-reduction during nicotine self-administration.Drug and alcohol dependence · 2019Article
- Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science.Behavior analysis (Washington, D.C.) · 2018Article
- Locomotor activity does not predict individual differences in morphine self-administration in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Heroin and saccharin demand and preference in rats.Drug and alcohol dependence · 2017Article
- Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.Psychopharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe FDA is considering reducing the nicotine content in tobacco products as a population-based strategy to reduce tobacco addiction. Research is needed to determine the threshold level of nicotine needed to maintain smoking and the extent of compensatory smoking that could occur during nicotine reduction. Sources of variability in these measures across sub-populations also need to be identified so that policies can take into account the risks and benefits of nicotine reduction in vulnerable populations.
methodsThe present study examined these issues in a rodent nicotine self-administration model of nicotine reduction policy to characterize individual differences in nicotine reinforcement thresholds, degree of compensation, and elasticity of demand during progressive reduction of the unit nicotine dose. The ability of individual differences in baseline nicotine intake and nicotine pharmacokinetics to predict responses to dose reduction was also examined.
resultsConsiderable variability in the reinforcement threshold, compensation, and elasticity of demand was evident. High baseline nicotine intake was not correlated with the reinforcement threshold, but predicted less compensation and less elastic demand. Higher nicotine clearance predicted low reinforcement thresholds, greater compensation, and less elastic demand. Less elastic demand also predicted lower reinforcement thresholds.
conclusionsThese findings suggest that baseline nicotine intake, nicotine clearance, and the essential value of nicotine (i.e. elasticity of demand) moderate the effects of progressive nicotine reduction in rats and warrant further study in humans. They also suggest that smokers with fast nicotine metabolism may be more vulnerable to the risks of nicotine reduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.