ReviewWiley interdisciplinary reviews. Systems biology and medicine
Systems medicine: evolution of systems biology from bench to bedside.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Network Analysis of the Multidimensional Symptom Experience of Oncology.Scientific reports · 2019Trial
- Shock Induced Endotheliopathy and High Trauma Mortality-Fight-or-Flight Response Revisited.International journal of molecular sciences · 2026Review
- A Translational Review of Mechanisms of Effectiveness of Photobiomodulation on Somatosensory Neurons and the Peripheral Nervous System-From Molecular Mechanisms to Clinical Applications in Medicine and Dentistry.Current issues in molecular biology · 2026Review
- Rethinking medical education through systems biology to address complexity.NPJ systems biology and applications · 2026Review
- Ethical challenges in biomarker research and precision medicine - a qualitative study in dermatology.BMC medical ethics · 2025Article
- AFrontiers in cardiovascular medicine · 2024Article
- Network analysis to identify symptoms clusters and temporal interconnections in oncology patients.Scientific reports · 2022Article
- Pathway Analysis for Cancer Research and Precision Oncology Applications.Advances in experimental medicine and biology · 2022Article
- Review
- The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases.International journal of molecular sciences · 2021Review
- PHENSIM: Phenotype Simulator.PLoS computational biology · 2021Article
- Methods to Develop anFrontiers in psychiatry · 2021Article
- Pulmonary arterial hypertension: Cellular and molecular changes in the lung.Global cardiology science & practice · 2020Review
- Patient Registries in Idiopathic Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2019Review
- Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.Theoretical medicine and bioethics · 2019Article
- Identification of Biomarkers in Neuropsychiatric Disorders Based on Systems Biology and Epigenetics.Frontiers in genetics · 2019Review
- Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds.NPJ systems biology and applications · 2019Article
- Systems Biology Approaches to Redox Metabolism in Stress and Disease States.Antioxidants & redox signaling · 2018Review
- New perspectives: systems medicine in cardiovascular disease.BMC systems biology · 2018Article
- E-health beyond technology: analyzing the paradigm shift that lies beneath.Medicine, health care, and philosophy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
High-throughput experimental techniques for generating genomes, transcriptomes, proteomes, metabolomes, and interactomes have provided unprecedented opportunities to interrogate biological systems and human diseases on a global level. Systems biology integrates the mass of heterogeneous high-throughput data and predictive computational modeling to understand biological functions as system-level properties. Most human diseases are biological states caused by multiple components of perturbed pathways and regulatory networks rather than individual failing components. Systems biology not only facilitates basic biological research but also provides new avenues through which to understand human diseases, identify diagnostic biomarkers, and develop disease treatments. At the same time, systems biology seeks to assist in drug discovery, drug optimization, drug combinations, and drug repositioning by investigating the molecular mechanisms of action of drugs at a system's level. Indeed, systems biology is evolving to systems medicine as a new discipline that aims to offer new approaches for addressing the diagnosis and treatment of major human diseases uniquely, effectively, and with personalized precision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.