Evidence map›Paper›PMID 25891082›Full record

ArticleActa pharmacologica Sinica2015

Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen).

Dan-dan Tian, Wei-wei Jia, Xin-wei Liu, Dan-dan Wang, Jun-hua Liu, Jia-jia Dong, Li Li, Fei-fei Du, Fang Xu, Feng-qing Wang and 8 more

Open access · hybridAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Acta pharmacologica Sinica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

5.7field-weighted citation impact, top 5% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule.Acta pharmacologica Sinica · 2021
Trial
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation.Acta pharmacologica Sinica · 2024
Article
Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids ofFrontiers in pharmacology · 2022
Article
The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications.Cancers · 2020
Review
High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care.Acta pharmaceutica Sinica. B · 2019
Article
Tanshinol inhibits the growth, migration and invasion of hepatocellular carcinoma cells via regulating the PI3K-AKT signaling pathway.OncoTargets and therapy · 2019
Article
Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease.International journal of molecular sciences · 2017
Review
BioMed research international · 2017
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Dan-dan Tian1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [2] University of Chinese Academy of Sciences, Shanghai 201203, China.

Wei-wei JiaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Xin-wei LiuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Dan-dan WangTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Jun-hua LiuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Jia-jia DongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Li LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Fei-fei DuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Fang XuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Feng-qing WangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Yan SunShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Yu-xing HuangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Mei-juan LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Li-hong HuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Yan ZhuTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Xiu-mei GaoTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Chuan Li1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [2] University of Chinese Academy of Sciences, Shanghai 201203, China [3] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Jun-ling Yang1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [2] University of Chinese Academy of Sciences, Shanghai 201203, China.

Shanghai Institute of Materia Medica · CNChinese Academy of Sciences · CNTianjin University of Traditional Chinese Medicine · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTanshinol is an important catechol in the antianginal herb Salvia miltiorrhiza roots (Danshen). This study aimed to characterize tanshinol methylation.

methodsMetabolites of tanshinol were analyzed by liquid chromatography/mass spectrometry. Metabolism was assessed in vitro with rat and human enzymes. The major metabolites were synthesized for studying their interactions with drug metabolizing enzymes and transporters and their vasodilatory properties. Dose-related tanshinol methylation and its influences on tanshinol pharmacokinetics were also studied in rats.

resultsMethylation, preferentially in the 3-hydroxyl group, was the major metabolic pathway of tanshinol. In rats, tanshinol also underwent considerable 3-O-sulfation, which appeared to be poor in human liver. These metabolites were mainly eliminated via renal excretion, which involved tubular secretion mainly by organic anion transporter (OAT) 1. The methylated metabolites had no vasodilatory activity. Entacapone-impaired methylation did not considerably increase systemic exposure to tanshinol in rats. The saturation of tanshinol methylation in rat liver could be predicted from the Michaelis constant of tanshinol for catechol-O-methyltransferase (COMT). Tanshinol had low affinity for human COMT and OATs; its methylated metabolites also had low affinity for the transporters. Tanshinol and its major human metabolite (3-O-methyltanshinol) exhibited negligible inhibitory activities against human cytochrome P450 enzymes, organic anion transporting polypeptides 1B1/1B3, multidrug resistance protein 1, multidrug resistance-associated protein 2, and breast cancer resistance protein.

conclusionTanshinol is mainly metabolized via methylation. Tanshinol and its major human metabolite have low potential for pharmacokinetic interactions with synthetic antianginal agents. This study will help define the risk of hyperhomocysteinemia related to tanshinol methylation.

Indexed as

Administration, OralAnimalsBiotransformationCaffeic AcidsCardiovascular AgentsCatechol O-MethyltransferaseChromatography, LiquidCytochrome P-450 Enzyme SystemDrugs, Chinese HerbalHerb-Drug InteractionsHumansInjections, IntravenousKidney TubulesLiverMaleMass SpectrometryCaffeic AcidsCardiovascular AgentsCatechol O-MethyltransferaseCytochrome P-450 Enzyme SystemDrugs, Chinese HerbalMembrane Transport ProteinsOrganic Anion Transport Protein 1Slc22a6 protein, ratSulfatestanshinol

Identifiers

PMID25891082

DOI10.1038/aps.2015.20

PMCPMC4422947

OpenAlexW1504733165

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.