ArticleAnnals of epidemiology2015
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.Circulation. Genomic and precision medicine · 2021Trial
- Developmental origins of exceptional health and survival: a four-generation family cohort study.Nature communications · 2026Article
- Familial healthy aging and longevity: the role of spouses.BMC medicine · 2026Article
- Physical resilience after a diagnosis of cardiovascular disease among offspring of long-lived siblings.European journal of ageing · 2022Article
- NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study.Aging cell · 2020Article
- Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.Atherosclerosis · 2020Article
- The Survival of Spouses Marrying Into Longevity-Enriched Families.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Genetics: Healthy ageing, the genome and the environment.Nature reviews. Endocrinology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 6 countries.
Funding
Abstract
purposeFamilial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.
methodsThe study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population.
resultsDuring the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95% confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer.
conclusionsThe low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.