ArticleBiomaterials2015
Macrophage silica nanoparticle response is phenotypically dependent.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury.Frontiers in immunology · 2022Pooled it
- uPAR-targeted stealth small-sized mesoporous silica nanoparticles for pancreatic cancer therapy.Drug delivery and translational research · 2026Article
- Modulation of Cell Signaling Pathways in Silica Nanoparticle-Saturated Macrophages.Pharmaceutics · 2026Article
- Evaluation of sources of variability in a nitric oxide screening assay for engineered nanomaterials.Nanomedicine : nanotechnology, biology, and medicine · 2026Article
- Sulfidation Affects Macrophage Uptake of Metal-Based Nanomaterials by Dictating Protein Corona Compositions and Aggregation States Collectively.Environment & health (Washington, D.C.) · 2025Article
- Effects of silica nanoparticles with varied physicochemical properties on the survival and functionality of saturated macrophages.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- The impact of macrophage phenotype and heterogeneity on the total internalized gold nanoparticle counts.Nanoscale advances · 2024Article
- Modulating Lipid-Polymer Nanoparticles' Physicochemical Properties to Alter Macrophage Uptake.ACS biomaterials science & engineering · 2024Article
- Macrophage Polarization Status Impacts Nanoceria Cellular Distribution but Not Its Biotransformation or Ferritin Effects.Nanomaterials (Basel, Switzerland) · 2023Article
- Interplay of Oxidative Stress, Inflammation, and Autophagy in RAW 264.7 Murine Macrophage Cell Line Challenged with Si/SiOMaterials (Basel, Switzerland) · 2023Article
- Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning.Pharmaceutics · 2023Article
- Targeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation.iScience · 2022Article
- Polymeric coating lubricates nanocontainers to escape macrophage uptake for bioreceptor recognition.Bioactive materials · 2022Article
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- Excess iron promotes emergence of foamy macrophages that overexpress ferritin in the lungs of silicosis patients.Respirology (Carlton, Vic.) · 2022Article
- Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging.Cell death discovery · 2021Article
- Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy.Pharmaceutics · 2021Review
- Cell relay-delivery improves targeting and therapeutic efficacy in tumors.Bioactive materials · 2021Article
- Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19.ACS biomaterials science & engineering · 2021Review
- Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M.Bioactive materials · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Phagocytes are important players in host exposure to nanomaterials. Macrophages in particular are believed to be among the "first responders" and primary cell types that uptake and process nanoparticles, mediating host biological responses by subsequent interactions with inflammatory signaling pathways and immune cells. However, variations in local microenvironmental cues can significantly change the functional and phenotype of these cells, impacting nanoparticle uptake and overall physiological response. Herein we focus on describing the response of specific RAW 264.7 macrophage phenotypes (M1, INF-gamma/LPS induced and M2, IL-4 induced) to Stöber silica nanoparticle exposure in vitro and how this response might correlate with macrophage response to nanoparticles in vivo. It was observed that variations in macrophage phenotype produce significant differences in macrophage morphology, silica nanoparticle uptake and toxicity. High uptake was observed in M1, versus low uptake in M2 cells. M2 cells also displayed more susceptibility to concentration dependent proliferative effects, suggesting potential M1 involvement in in vivo uptake. Nanoparticles accumulated within liver and spleen tissues, with high association with macrophages within these tissues and an overall Th1 response in vivo. Both in vitro and in vivo studies are consistent in demonstrating that silica nanoparticles exhibit high macrophage sequestration, particularly those with Th1/M1 phenotype and in clearance organs. This sequestration and phenotypic response should be a primary consideration when designing new Stöber silica nanoparticle systems, as it might affect the overall efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.