ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2015
Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- The effect of opium consumption on prostate cancer among Iranian patients: A retrospective analytical study.Medicine · 2026Article
- Noscapine and Apoptosis in Breast and Other Cancers.International journal of molecular sciences · 2024Review
- Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application.Molecules (Basel, Switzerland) · 2023Review
- Article
- Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo.International journal of microbiology · 2023Article
- Review
- In Vitro Effects of Papaverine on Cell Migration and Vascular Endothelial Growth Factor in Cancer Cell Lines.International journal of molecular sciences · 2022Article
- In Vitro Effects of Papaverine on Cell Proliferation, Reactive Oxygen Species, and Cell Cycle Progression in Cancer Cells.Molecules (Basel, Switzerland) · 2021Article
- Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development.Advanced pharmaceutical bulletin · 2021Review
- Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia.Pharmacological reports : PR · 2021Article
- Novel Papaverine Metal Complexes with Potential Anticancer Activities.Molecules (Basel, Switzerland) · 2020Article
- Impact of Opioid Use in Hematological Malignancies: Clinical, Immunological and Concomitant Aspects.Journal of hematology · 2020Review
- The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer.Molecules (Basel, Switzerland) · 2020Article
- 3'O-Methyltransferase, Ps3'OMT, from opium poppy: involvement in papaverine biosynthesis.Plant cell reports · 2019Article
- Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells.PloS one · 2019Article
- Update of the Scientific Opinion on opium alkaloids in poppy seeds.EFSA journal. European Food Safety Authority · 2018Article
- Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytotoxic effects of some of the members of papaveraceae family have been reported in Iranian folk medicine. Recent reports has indicated that alkaloids fraction of opium may be responsible for its cytotoxic effect; however, the mechanism of this effect is not fully understood. This study has been designed to investigate the selective cytotoxic, genotoxic and also apoptosis induction effects of noscapine, papaverine and narceine, three non-addictable opium alkaloids, on HT29, T47D and HT1080 cancer cell lines. Mouse NIH3T3 cell line was chosen to present non-cancerous cells and Doxorubicin was selected as the positive control.
methodsCells were treated by different concentrations of Noscapine, Papaverine, Narceine and doxorubicin; viability was assessed by MTT assay. The genotoxicity and apoptosis induction were tested with comet assay and Annexin-V affinity when the concentration of each these drugs is less than its IC50. In addition, the DNA damage and caspase activity of the T47D cells were examined and the results were compared.
resultsThis study noted the cytotoxicity and genotoxicity of noscapine and papaverine, specifically on cancerous cell lines. Furthermore, papaverine induces apoptosis in all studied cancer cell lines and noscapine showed this effect in T47D and HT29 cells but not in NIH-3 T3 cells as noncancerous cell line. narceine also showed genototoxicity in the studied cell lines at its IC50 concentration.
conclusionsThis experiment suggests that noscapine and papaverine may be of use in cancer treatment due to their specific cytotoxicity and genotoxicity. However, further in vivo studies are needed to confirm its usefulness in cancer treatment.
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