ArticleMalaria journal2015
In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comprehensive review of antimalarial medicinal plants used by Tanzanians.Pharmaceutical biology · 2024Pooled it
- The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers.Malaria journal · 2024Trial
- Lupane Triterpenes with Antileukemia Activity fromACS omega · 2026Article
- A Review of the Phytochemistry, Molecular Docking, Pharmacology, Toxicology, Ethnopharmacology, Botany, and Clinical Studies ofBiomolecules · 2025Review
- Ethnopharmacological considerations of plants traditionally used by local communities to manage maternal conditions in Tanzania: a scoping review.Frontiers in pharmacology · 2025Review
- Isolation and Identification of Phytocompounds fromMolecules (Basel, Switzerland) · 2023Article
- A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score.Malaria journal · 2023Review
- Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19.Physics and chemistry of the earth (2002) · 2022Article
- Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers: An Open-Label, Single-Arm, Dose-Escalation Study onTropical medicine and infectious disease · 2022Article
- Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry.Chinese medicine · 2022Review
- Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria.European journal of integrative medicine · 2022Article
- A review on anti-peptic ulcer activities of medicinal plants used in the formulation ofHeliyon · 2021Review
- Article
- A Review on Phytochemicals of the GenusMolecules (Basel, Switzerland) · 2021Review
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Antimalarial Plants Used across Kenyan Communities.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data.Evidence-based complementary and alternative medicine : eCAM · 2019Review
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Tanzania and elsewhere, medicinal plants, including Maytenus senegalensis, are still widely used in the treatment of malaria and other ailments. The aim of the present study was to investigate the in vivo antiplasmodial and toxic effects in mice.
methodsOral antiplasmodial and acute toxicity of the ethanolic root extract of M. senegalensis was evaluated in mice. The Peters 4-day in vivo antiplasmodial effect against early rodent malaria infection in chloroquine-sensitive Plasmodium berghei NK 65 strain in mice.
resultsThe M. senegalensis extract was found non-toxic and the oral median lethal dose in mice was determined to be greater than 1,600 mg/kg body weight. The findings revealed a significant (P = 0.001) daily increase in the level of parasitaemia in the parasitized untreated groups and a significant (P < 0.001) dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses ranging from 25 to 100 mg/kg body weight of M. senegalensis extract and the standard drug sulphadoxine/pyrimethamine at 25/1.25 mg/kg body weight. Overall, the dose dependent parasitaemia suppression effects were in the order of: 25/1.25 mg/kg body weight of sulphadoxine/pyrimethamine > 100 mg/kg > 75 mg/kg > 50 mg/kg > 25 mg/kg body weight of M. senegalensis extract.
conclusionThe implications of these findings is that M. senegalensis ethanolic root bark extract possess potent antiplasmodial effect and may, therefore, serve as potential sources of safe, effective and affordable anti-malarial drugs. The displayed high in vivo antiplasmodial activity and lack of toxic effect render M. senegalensis a candidate for the bioassay-guided isolation of compounds which could develop into new lead structures and candidates for drug development programmes against human malaria.
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