ArticleJournal of translational medicine2015
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.
Article in Journal of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes.The Journal of clinical investigation · 2021Trial
- Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.PloS one · 2018Trial
- Association between adiposity and facial aging: results from a Mendelian randomization study.European journal of medical research · 2023Article
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- Physical Activity and Its Barriers and Facilitators among University Students in Qatar: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Screening of Obese Offspring of First-Cousin Consanguineous Subjects for the Angiotensin-Converting Enzyme Gene with a 287-bp Alu Sequence.Journal of obesity & metabolic syndrome · 2021Article
- Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.NPJ genomic medicine · 2021Article
- Precision medicine in the era of artificial intelligence: implications in chronic disease management.Journal of translational medicine · 2020Review
- Qatari Genotype May Contribute to Complications in Type 2 Diabetes.Journal of diabetes research · 2020Article
- A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.Frontiers in endocrinology · 2019Article
- Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.Journal of lipid research · 2018Article
- Five-year Outcomes of Laparoscopic Sleeve Gastrectomy: a Comparison Between Adults and Adolescents.Obesity surgery · 2018Article
- Functional Stroke Mimics: Incidence and Characteristics at a Primary Stroke Center in the Middle East.Psychosomatic medicine · 2018Article
- Outcomes of Laparoscopic Gastric Greater Curvature Plication in Morbidly Obese Patients.Journal of obesity · 2017Article
- Type 2 Diabetes Risk Allele Loci in the Qatari Population.PloS one · 2016Article
- Article
- Discovering Novel Biochemical and Genetic Markers for Coronary Heart Disease in Qatari Individuals: The Initiative Qatar Cardiovascular Biorepository.Heart views : the official journal of the Gulf Heart AssociationArticle
Corrections and comments
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Authors and funding
28 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population.
methodsEight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan.
resultsTwo loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358).
conclusionWe showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.