Evidence map›Paper›PMID 25890251›Full record

Trial reportStem cell research & therapy2015

Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial).

Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins, Rodrigo Jorge

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stem cell research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01560715 (Phase 2 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01560715 phase2completednot on this map

Phase 2 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa

TypeinterventionalSponsorUniversity of Sao PauloRan2011 to 2013Enrolled50ConditionsRetinitis PigmentosaArmsintravitreal injection of autologous bone marrow stem cells
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rubens C SiqueiraDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rubenssiqueira@terra.com.br.
Andre MessiasDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. amessias@hotmail.com.
Katharina MessiasDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. Katharina.Messias@gmail.com.
Rafael S ArcieriDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rsarc@bol.com.br.
Milton A RuizDepartment of Bone Marrow Transplantation, Beneficencia Portuguesa Hospital, Sao Jose do Rio Preto, SP, Brazil. milruiz@yahoo.com.br.
Neiglene F SouzaRubens Siqueira Research Center, Sao Jose do Rio Preto, SP, Brazil. Neiglene@hotmail.com.
Lia C MartinsDiscipline of Biology, Paulista University (UNIP), Sao Jose do Rio Preto, SP, Brazil. liacampanha1@gmail.com.
Rodrigo JorgeDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. retinausp@hotmail.com.
Universidade de São Paulo · BRBeneficência Portuguesa de São Paulo · BRUniversidade Paulista · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRetinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the results are being evaluated. In the present report we assess the vision-related quality of life in patients with RP submitted to intravitreal use of bone marrow-derived stem cells.

methodThe study included 20 patients with RP submitted to intravitreal use of bone marrow-derived stem cells. We evaluate the vision-related quality of life (VRQOL) of patients using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Patients were scheduled to answer the questionnaire before treatment and 3 and 12 months after treatment.

resultsAll patients completed the survey as scheduled. There was a statistically significant improvement (P<0.05) in the quality of life of patients 3 months after treatment, whereas by the 12th month there was no statistically significant difference from baseline.

conclusionsCell therapy with intravitreal use of bone marrow-derived stem cells can improve the quality of life of patients with RP, although the improvement is lost with time. A larger number of cases will be necessary to evaluate the repercussions of this therapy on the quality of life of these patients.

trial registrationClinicaltrials.gov: NCT01560715 . Registered March 19, 2012.

Indexed as

Quality of LifeStem Cell TransplantationBone Marrow CellsCell- and Tissue-Based TherapyHumansRetinitis PigmentosaStem CellsSurveys and QuestionnairesVision, Ocular

Identifiers

PMID25890251
PMCPMC4393588
OpenAlexW2163328478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.