Evidence map›Paper›PMID 25890065›Full record

ReviewCurrent opinion in virology2015

Landscape of post-transcriptional gene regulation during hepatitis C virus infection.

Johannes Schwerk, Abigail P Jarret, Rochelle C Joslyn, Ram Savan

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The mRNA Cap 2'-mSphere · 2020
    Article
  6. Altered mMolecular cell · 2020
    Article
  7. Review
  8. Article
  9. Article
  10. Translating the Untranslated Region.Journal of immunology (Baltimore, Md. : 1950) · 2015
    Review
  11. Editorial overview: Antiviral strategies.Current opinion in virology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Johannes SchwerkDepartment of Immunology, University of Washington, Seattle, WA 98109, USA.
Abigail P JarretDepartment of Immunology, University of Washington, Seattle, WA 98109, USA.
Rochelle C JoslynDepartment of Immunology, University of Washington, Seattle, WA 98109, USA.
Ram SavanDepartment of Immunology, University of Washington, Seattle, WA 98109, USA. Electronic address: savanram@uw.edu.
University of Washington · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Novel regulatory mechanisms control IFNL3 expression during HCV infectionR01AI108765 · NIAID · UNIVERSITY OF WASHINGTON · PI SAVAN, RAM · 2014 to 2018
$2.3M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
NCATS NIH HHS TL1 TR000422NCATS NIH HHS UL1 TR002319NIAID NIH HHS 1R01AI108765-01NIAID NIH HHS R01 AI108765
6 · The paper itself

Abstract

Post-transcriptional regulation of gene expression plays a pivotal role in various gene regulatory networks including, but not limited to metabolism, embryogenesis and immune responses. Different mechanisms of post-transcriptional regulation, which can act individually, synergistically, or even in an antagonistic manner have been described. Hepatitis C virus (HCV) is notorious for subverting host immune responses and indeed exploits several components of the host's post-transcriptional regulatory machinery for its own benefit. At the same time, HCV replication is post-transcriptionally targeted by host cell components to blunt viral propagation. This review discusses the interplay of post-transcriptional mechanisms that affect host immune responses in the setting of HCV infection and highlights the sophisticated mechanisms both host and virus have evolved in the race for superiority.

Indexed as

Gene Expression RegulationRNA Processing, Post-TranscriptionalHepacivirusHepatitis CHost-Pathogen InteractionsHumansMicroRNAsModels, GeneticRNA-Binding ProteinsRNA, Long NoncodingMicroRNAsRNA-Binding ProteinsRNA, Long Noncoding

Identifiers

PMID25890065
PMCPMC4472456
OpenAlexW2027155885

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.