Evidence map›Paper›PMID 25890013›Full record

ArticleRadiation oncology (London, England)2015

A comparative assessment of prostate positioning guided by three-dimensional ultrasound and cone beam CT.

Minglun Li, Hendrik Ballhausen, Nina-Sophie Hegemann, Ute Ganswindt, Farkhad Manapov, Stefan Tritschler, Alexander Roosen, Christian Gratzke, Michael Reiner, Claus Belka

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Comparison of prostate positioning guided by three-dimensional transperineal ultrasound and cone beam CT.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017
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  16. Prefraction displacement and intrafraction drift of the prostate due to perineal ultrasound probe pressure.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minglun LiDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. minglun.li@med.uni-muenchen.de.
Hendrik BallhausenDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Hendrik.Ballhausen@med.uni-muenchen.de.
Nina-Sophie HegemannDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Nina-Sophie.Hegemann@med.uni-muenchen.de.
Ute GanswindtDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Ute.Ganswindt@med.uni-muenchen.de.
Farkhad ManapovDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Farkhad.Manapov@med.uni-muenchen.de.
Stefan TritschlerDepartment of Urology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Stefan.Tritschler@med.uni-muenchen.de.
Alexander RoosenDepartment of Urology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Alexander.Roosen@med.uni-muenchen.de.
Christian GratzkeDepartment of Urology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Christian.Gratzke@med.uni-muenchen.de.
Michael ReinerDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Michael.Reiner@med.uni-muenchen.de.
Claus BelkaDepartment of Radiation Oncology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Claus.Belka@med.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe accuracy of the Elekta Clarity™ three-dimensional ultrasound system (3DUS) was assessed for prostate positioning and compared to seed- and bone-based positioning in kilo-voltage cone-beam computed tomography (CBCT) during a definitive radiotherapy.

methodsThe prostate positioning of 6 patients, with fiducial markers implanted into the prostate, was controlled by 3DUS and CBCT. In total, 78 ultrasound scans were performed trans-abdominally and compared to bone-matches and seed-matches in CBCT scans. Setup errors detected by the different modalities were compared. Systematic and random errors were analysed, and optimal setup margins were calculated.

resultsThe discrepancy between 3DUS and seed-match in CBCT was -0.2 ± 2.7 mm laterally, -1.9 ± 2.3 mm longitudinally and 0.0 ± 3.0 mm vertically and significant only in longitudinal direction. Using seed-match as reference, systematic errors of 3DUS were 1.3 mm laterally, 0.8 mm longitudinally and 1.4 mm vertically, and random errors were 2.5 mm laterally, 2.3 mm longitudinally, and 2.7 mm vertically. No significant difference could be detected for 3DUS in comparison to bone-match in CBCT.

conclusions3DUS is feasible for image guidance for patients with prostate cancer and appears comparable to CBCT based image guidance in the retrospective study. While 3DUS offers some distinct advantages such as no need of invasive fiducial implantation and avoidance of extra radiation, its disadvantages include the operator dependence of the technique and dependence on sufficient bladder filling. Further study of 3DUS for image guidance in a large patient cohort is warranted.

Indexed as

Cone-Beam Computed TomographyRadiotherapy, Intensity-ModulatedFeasibility StudiesFiducial MarkersHumansImaging, Three-DimensionalMaleOrgans at RiskPatient PositioningProstateProstatic NeoplasmsRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedRadiotherapy Setup ErrorsRectumReproducibility of Results

Identifiers

PMID25890013
PMCPMC4465303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.