ArticleParasites & vectors2015
First report of Anaplasma platys infection in red foxes (Vulpes vulpes) and molecular detection of Ehrlichia canis and Leishmania infantum in foxes from Portugal.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Anaplasma platys beyond canines: a systematic review of host range, phylogenetic relatedness, and knowledge gaps in Africa.Parasites & vectors · 2026Pooled it
- Isolation ofOne health (Amsterdam, Netherlands) · 2026Article
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- Leishmania infantum in red foxes (Vulpes vulpes): from clinical findings to cytokine expression.Parasites & vectors · 2026Article
- Molecular analysis of vector-borne pathogens in red foxes (International journal for parasitology. Parasites and wildlife · 2025Article
- Molecular and Serological Detection ofAnimals : an open access journal from MDPI · 2025Article
- Epidemiological Significance of the Fox (Pathogens (Basel, Switzerland) · 2025Article
- Molecular survey of tick-borne pathogens in domestic dogs from a rural region within the buffer zone of a conservation unit in the Brazilian Caatinga biome.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Article
- Molecular detection ofVeterinary world · 2024Article
- First molecular evidence ofOpen veterinary journal · 2024Article
- Transmission risk of vector-borne bacterial diseases (Anaplasma spp. and Ehrlichia canis) in Spain and Portugal.BMC veterinary research · 2024Article
- Alternative hosts of Leishmania infantum: a neglected parasite in Europe.Tropical animal health and production · 2024Review
- Article
- Molecular Detection and Phylogenetic Characterization ofVeterinary sciences · 2023Article
- Arthropod-Borne Pathogens in Wild Canids.Veterinary sciences · 2023Review
- Occurrence of Bacterial and Protozoan Pathogens in Red Foxes (Animals : an open access journal from MDPI · 2022Article
- Red Foxes (Pathogens (Basel, Switzerland) · 2022Article
- New Epidemiological Aspects of Animal Leishmaniosis in Europe: The Role of Vertebrate Hosts Other Than Dogs.Pathogens (Basel, Switzerland) · 2021Review
- Molecular detection of tick-borne pathogens in caracals (Caracal caracal) living in human-modified landscapes of South Africa.Parasites & vectors · 2020Article
- Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe bacteria Anaplasma platys and Ehrlichia canis and the protozoan Leishmania infantum are vector-borne agents that cause canine vector-borne diseases, some of which are zoonotic. The present survey investigated the prevalence of Anaplasma, Ehrlichia and Leishmania in red foxes (Vulpes vulpes) from Portugal by molecular analysis, in order to evaluate the epidemiological role of these canids as reservoirs of infection.
methodsBlood and/or bone marrow samples were collected from 78 red foxes obtained in eight districts of northern, central and southern Portugal. Real-time polymerase chain reactions (PCR) amplified a 123 bp fragment of the 16S rRNA gene of Anaplasma spp. and Ehrlichia spp. and a 265 bp fragment of the L. infantum internal transcribed spacer one (ITS1) region of the rRNA operon evaluated by PCR-high resolution melt analysis (PCR-HRM), with sequencing of the DNA products. A phylogenetic analysis was carried out to compare these to other sequences from Anaplasma spp. and Ehrlichia spp. deposited in GenBank.
resultsA. platys was detected in 10 (14.5%) and E. canis in two (2.9%) out of 69 foxes; and L. infantum was detected in one (1.3%) of the 78 foxes. The prevalence of A. platys was significantly different from the prevalence of E. canis (p=0.016) and from that of L. infantum (p=0.002). No co-infections were found in any one of the 78 foxes. No statistically significant differences were found between the type of sample (blood and bone marrow), geographic regions (north/centre and south), age (<2 years and ≥2 years) and gender for any one of the agents.
conclusionsThis is the first known report of A. platys in red foxes worldwide, as well as the first molecular evidence of E. canis in foxes from Portugal. The moderate prevalence of A. platys suggests that red foxes may play a role in the epidemiology of infection with this bacterium and serve as a reservoir for domestic dogs.
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