Evidence map›Paper›PMID 25889669›Full record

SynthesisEuropean journal of medical research2015

Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis.

Jatupon Kongtharvonskul, Thunyarat Anothaisintawee, Mark McEvoy, John Attia, Patarawan Woratanarat, Ammarin Thakkinstian

2 registry-linked trialsOpen access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03106584 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Investigating the Potential for Marigot's Nutrition Supplement to Improve Symptoms and Physical Function in Those With Mild to Moderate Knee Osteoarthritis (KOA) Versus the Current Market Leader (Glucosamine Sulphate)

TypeinterventionalSponsorUniversity College DublinRan2017 to 2017Enrolled30ConditionsKnee OsteoarthritisArmsAquamin-Plus, Glucosamine sulphate
NCT07549386 phase3completednot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Etoricoxib 90 mg + Diacerein 50 mg Capsule Compared to Meloxicam 15 mg + Diacerein 50 mg in Patients With Knee and/or Hip Osteoarthritis: A Phase III, Controlled, Randomized, Double-blind, Multicenter Clinical Trial.

TypeinterventionalSponsorLaboratorios LiomontRan2024 to 2025Enrolled123ConditionsPain Management, OsteoarthritisArmsEtoricoxib 90 mg + diacerein 50 mg, Meloxicam 15 mg + diacerein 50 mg
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  8. USING ARTHROSCOPY TO OBSERVE THE EFFECT OF LIVER-SOFTENING MEDICINE ON KNEE OSTEOARTHRITIS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017
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  16. Chaenomeles Fructus (CF), the Fruit ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jatupon KongtharvonskulSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Faculty of Medicine Ramathibodi Hospital, Ratchathewi, Chang Wat Bangkok, Bangkok, 10400, Thailand. Jatupon_kong@hotmail.com.
Thunyarat AnothaisintaweeSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Faculty of Medicine Ramathibodi Hospital, Ratchathewi, Chang Wat Bangkok, Bangkok, 10400, Thailand. ratan@mahidol.ac.th.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, The University of Newcastle, University Drive, Newcastle, NSW 2308, Australia. McEvoy@newctle.edu.au.
John AttiaCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia. john.attia@newcastle.edu.au.
Patarawan WoratanaratDepartment of Orthopaedics, Faculty of Medicine Ramathibodi Hospital, Bangkok, Mahidol University, Highway 3310, Bangkok, 73170, Thailand. patarawan.wor@mahidol.ac.th.
Ammarin ThakkinstianSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Faculty of Medicine Ramathibodi Hospital, Ratchathewi, Chang Wat Bangkok, Bangkok, 10400, Thailand. ammarin.tha@mahidol.ac.th.
Ramathibodi Hospital · THHunter Medical Research Institute · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) scores, Lequesne algofunctional index, joint space width change, and adverse events) between diacerein, glucosamine, and placebo.

methodsMedline and Scopus databases were searched from inception to 29 August 2014, using PubMed and Scopus search engines and included RCTs or quasi-experimental designs comparing clinical outcomes between treatments. Data were extracted from original studies. A network meta-analysis was performed by applying weight regression for continuous outcomes and a mixed-effect Poisson regression for dichotomous outcomes.

resultsThirty-one of 505 identified studies were eligible. Compared to placebo, glucosamine showed a significant improvement with unstandardized mean differences (UMD) in total WOMAC, pain WOMAC, function WOMAC, and Lequesne score of -2.49 (95% confidence interval (CI) -4.14, -0.83), -0.75 (95% CI: -1.18, -0.32), -4.78 (95% CI: -5.96, -3.59), and -1.03 (95% CI: -1.34, -0.72), respectively. Diacerein clinically improves visual analog scores, function WOMAC, and stiffness WOMAC with UMD values of -2.23 (95% CI: -2.82, -1.64), -6.64 (95% CI: -10.50, -2.78), and -0.68 (95% CI: -1.20, -0.16) when compared to placebo.

conclusionsThe network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.

Indexed as

AnthraquinonesAnti-Inflammatory Agents, Non-SteroidalGlucosamineHumansOsteoarthritis, KneeAnthraquinonesAnti-Inflammatory Agents, Non-SteroidaldiacereinGlucosamine

Identifiers

PMID25889669
PMCPMC4359794
OpenAlexW2157301871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.