ArticleWorld journal of surgical oncology2015
Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.
Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.JNCI cancer spectrum · 2025Pooled it
- Higher-order multiple primary cancers and persistent cross-site risk across human papillomavirus-related anatomical sites in the United States: a population-based Surveillance, Epidemiology, and End Results study.Preventive medicine reports · 2026Article
- Metachronous gastro-oesophageal adenocarcinoma in a patient with colon adenocarcinoma.BMJ case reports · 2025Article
- Receipt of follow-up care plans on colorectal cancer screening among breast, prostate, and lung cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- Colorectal cancer screening utilization among breast, cervical, prostate, skin, and lung cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- The Effectiveness of Screening Total Colonoscopy for Preoperative Patients with Gastric Cancer.Annals of surgical oncology · 2024Article
- ASO Author Reflections: Significance of Colorectal Cancer Screening Through Preoperative Total Colonoscopy for Gastric Cancer.Annals of surgical oncology · 2024Article
- Three cancers in the renal pelvis, bladder, and colon: A case report.World journal of clinical cases · 2024Article
- Retrospective cohort study investigating association between precancerous gastric lesions and colorectal neoplasm risk.Frontiers in oncology · 2024Article
- Triple Primary Malignancies: Tumor Associations, Survival, and Clinicopathological Analysis: A 25-Year Single-Institution Experience.Healthcare (Basel, Switzerland) · 2023Article
- Clinical features and survival of patients with multiple primary malignancies.World journal of clinical cases · 2021Article
- Heterochronic triple primary malignancies with Epstein-Barr virus infection and tumor protein 53 gene mutation: A case report and review of literature.World journal of clinical cases · 2021Article
- Multiple primary malignancies of six organs in a Japanese male patient: A case report.Molecular and clinical oncology · 2019Article
- A Rare Occurrence of Three Primary Malignancies of the Rectum, Breast, and Kidney in the Same Patient: A Case Report and Review of the Literature.Case reports in surgery · 2019Article
- Lung cancer patients with synchronous colon cancer.Molecular and clinical oncology · 2018Article
- Comparisons of Gut Microbiota Among Healthy Control, Patients With Conventional Adenoma, Sessile Serrated Adenoma, and Colorectal Cancer.Journal of cancer prevention · 2017Article
- Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors.Medicine · 2017Observational
- Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study.OncoTargets and therapy · 2017Article
- Hereditary gastrointestinal cancer.Surgery today · 2016Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImprovement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC.
methodsWe reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs. As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC.
resultsMultiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients. By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001).
conclusionPatients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC.
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