ArticleWorld journal of surgical oncology2015
Differential diagnosis of benign and malignant breast masses using diffusion-weighted magnetic resonance imaging.
Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Can apparent diffusion coefficient (ADC) distinguish breast cancer from benign breast findings? A meta-analysis based on 13 847 lesions.BMC cancer · 2019Pooled it
- Prognostic prediction model for rectal cancer based on CMS subtype indicators and SHAP-based interpretable analysis.Abdominal radiology (New York) · 2026Article
- Optimization of the Non-Local Means Algorithm for Breast Diffusion-Weighted Magnetic Resonance Imaging Using a 3D-Printed Breast-Mimicking Phantom.Life (Basel, Switzerland) · 2025Article
- Multimodal apparent diffusion MRI model in noninvasive evaluation of breast cancer and Ki-67 expression.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Effect of contrast agent on T2-weighted fat-suppressed imaging and diffusion-weighted imaging in the diagnosis of breast tumors.Quantitative imaging in medicine and surgery · 2024Article
- Optimal selection of b-values for differential diagnosis of mediastinal lymph nodes using diffusion-weighted imaging.Heliyon · 2023Article
- Simplified intravoxel incoherent motion DWI for differentiating malignant from benign breast lesions.European radiology experimental · 2022Article
- Can DWI provide additional value to Kaiser score in evaluation of breast lesions.European radiology · 2022Article
- High-Resolution DWI with Simultaneous Multi-Slice Readout-Segmented Echo Planar Imaging for the Evaluation of Malignant and Benign Breast Lesions.Diagnostics (Basel, Switzerland) · 2021Article
- Differential diagnosis of plasma cell mastitis and invasive ductal carcinoma using multiparametric MRI.Gland surgery · 2020Article
- Diagnostic value of diffusion-weighted imaging-derived apparent diffusion coefficient and its association with histological prognostic factors in breast cancer.Oncology letters · 2019Article
- Ability ofContrast media & molecular imaging · 2019Article
- Dual-Phase ADC Modelling of Breast Masses in Diffusion-Weighted Imaging: Comparison with Histopathologic Findings.European journal of breast health · 2018Article
- Diagnostic evaluations of ultrasound and magnetic resonance imaging in mammary duct ectasia and breast cancer.Oncology letters · 2018Article
- Optimization of intra-voxel incoherent motion measurement in diffusion-weighted imaging of breast cancer.Journal of applied clinical medical physics · 2017Article
- Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values.European radiology · 2017Article
- Variability and bias assessment in breast ADC measurement across multiple systems.Journal of magnetic resonance imaging : JMRI · 2016Article
- Value of diffusion-weighted imaging combined with conventional magnetic resonance imaging in the diagnosis of thecomas/fibrothecomas and their differential diagnosis with malignant pelvic solid tumors.World journal of surgical oncology · 2016Article
- Diffusion weighted imaging in breast cancer - Can it be a noninvasive predictor of nuclear grade?The Indian journal of radiology & imagingArticle
- Qualitative and quantitative diffusion-weighted imaging of the breast at 3T - A useful adjunct to contrast-enhanced MRI in characterization of breast lesions.The Indian journal of radiology & imagingArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiffusion-weighted magnetic resonance imaging (DW-MRI) is different from conventional diagnostic methods and has the potential to delineate the microscopic anatomy of a target tissue or organ. The purpose of our study was to evaluate the value of DW-MRI in the diagnosis of benign and malignant breast masses, which would help the clinical surgeon to decide the scope and pattern of operation.
methodsA total of 52 female patients with palpable solid breast masses received breast MRI scans using routine sequences, dynamic contrast-enhanced imaging, and diffusion-weighted echo-planar imaging at b values of 400, 600, and 800 s/mm(2), respectively. Two regions of interest (ROIs) were plotted, with a smaller ROI for the highest signal and a larger ROI for the overall lesion. Apparent diffusion coefficient (ADC) values were calculated at three different b values for all detectable lesions and from two different ROIs. The sensitivity, specificity, positive predictive value, and positive likelihood ratio of DW-MRI were determined for comparison with histological results.
resultsA total of 49 (49/52, 94.2%) lesions were detected using DW-MRI, including 20 benign lesions (two lesions detected in the same patient) and 29 malignant lesions. Benign lesion had a higher mean ADC value than their malignant counterparts, regardless of b value. According to the receiver operating characteristic (ROC) curve, the smaller-range ROI was more effective in differentiation between benign and malignant lesions. The area under the ROC curve was the largest at a b value of 800 s/mm(2). With a threshold ADC value at 1.23 × 10(-3) mm(2)/s, DW-MRI achieved a sensitivity of 82.8%, specificity of 90.0%, positive predictive value of 92.3%, and positive likelihood ratio of 8.3 for differentiating benign and malignant lesions.
conclusionsDW-MRI is an accurate diagnostic tool for differentiation between benign and malignant breast lesions, with an optimal b value of 800 s/mm(2). A smaller-range ROI focusing on the highest signal has a better differential value.
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