Evidence map›Paper›PMID 25889316›Full record

ArticleBMC research notes2015

Classic Kaposi Sarcoma: to treat or not to treat?

Bruno Vincenzi, Loretta D'Onofrio, Anna Maria Frezza, Rosario Francesco Grasso, Valentina Fausti, Daniele Santini, Angelo Paolo Dei Tos, Giuseppe Tonini

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bruno VincenziDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. b.vincenzi@unicampus.it.
Loretta D'OnofrioDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. l.donofrio@unicampus.it.
Anna Maria FrezzaDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. a.frezza@unicampus.it.
Rosario Francesco GrassoDepartment of Radiology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. r.grasso@unicampus.it.
Valentina FaustiDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. v.fausti@alcampus.it.
Daniele SantiniDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. d.santini@unicampus.it.
Angelo Paolo Dei TosDepartment of Pathology, General Hospital, P.zza Ospedale 1, Treviso, Italy. apdeitos@me.com.
Giuseppe ToniniDepartment of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy. g.tonini@unicampus.it.
Università Campus Bio-Medico · ITCa' Foncello Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClassic Kaposi Sarcoma (KS) is vascular sarcoma, known to be more common in Mediterranean elderly men and characterized by an indolent clinical behavior. To our knowledge, this is the first evidence in literature, describing a spontaneous partial regression in a non-HIV, non-iatrogenic KS. CASE PRESENTATION: A 68-years old woman, presenting with weight loss and respiratory symptoms, was diagnosed with a classic KS involving lungs and mediastinal lymph nodes. No skin or mucosal lesions were identified, HIV positivity was ruled out. Due to patient's choice, she was kept under surveillance with 3-monthly thorax-abdomen-pelvis computed tomography scan (TAP CT). A first reassessment proved progressive disease (PD) associated with symptoms worsening. A new TAP CT, performed at 5 months from the diagnosis, showed stable disease (SD), with a minor reduction in size of mediastinal lymphadenopathies. A further reassessment, performed 5 months later, resulted in a partial response (PR) despite the absence of any medical treatment. Up to date, the disease is in remission, patient is asymptomatic and still on surveillance.

conclusionGiven the possible indolent behaviour of KS, we believe that close surveillance can represent a valuable approach in selected cases.

Indexed as

Neoplasm Regression, SpontaneousWatchful WaitingAgedFemaleHumansLungLymph NodesSarcoma, Kaposi

Identifiers

PMID25889316
PMCPMC4395989
OpenAlexW2092339272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.