ArticleBiomedical engineering online2015
Effects of heat conduction on the spatial selectivity of infrared stimulation in the cochlea.
Article in Biomedical engineering online, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo.Scientific reports · 2021Article
- Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.Lasers in medical science · 2017Article
- Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser.Lasers in medical science · 2017Article
- A contrastive analysis of laser heating between the human and guinea pig cochlea by numerical simulations.Biomedical engineering online · 2016Article
- Performance analysis of the beam shaping method on optical auditory neural stimulation in vivo.Lasers in medical science · 2015Article
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4 authors.
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Abstract
backgroundIt has been reported that one of the main mechanisms that induces the activation of the cochlea through infrared laser light is the photothermal effect. The temperature in the spiral ganglion cells increases as a result of photon absorption. However, heat conduction can induce an increase in the temperature within the cochlea and change the spatial selectivity of activation.
methodsWe analyzed the effects of heat conduction on the increase in temperature within the cochlea using a 3D model that simplifies the spiraled cochlea as a rotational symmetric structure . The model is solved using the finite element method.
resultsTaken as an example, the cochlea is stimulated by laser pulses at eight sites in its first turn. The temperature rise in time domain and spatial domain is simulated for different laser pulse energies and repetition rates. The results demonstrate that the temperature in the cochlea increases as the laser pulse energy and repetition rate increase. Additionally, the zone affected by the laser is enlarged because of the heat conduction in the surrounding structures. As a result, more auditory neurons can be stimulated than the expected.
conclusionsThe heat conduction affects the laser spatial selectivity however, by adjusting the stimulation schemes of the laser pulse-trains, such as laser repetition rate and laser power, the laser selectivity can be optimized.
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