ReviewJournal of physiological anthropology2015
Natural environments, ancestral diets, and microbial ecology: is there a modern "paleo-deficit disorder"? Part II.
Review in Journal of physiological anthropology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- Modulation of Gut Bacterial and Fungal Microbiota in Fibromyalgia Patients Following a Carb-Free Oloproteic Diet: Evidence for Candida Suppression and Symptom Improvement.Microorganisms · 2025Article
- A Journey into the Evolution of Human Host-Oral Microbiome Relationship through Ancient Dental Calculus: A Scoping Review.Microorganisms · 2024Article
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- Nutrition and Health in Human Evolution-Past to Present.Nutrients · 2022Review
- Lifestyle Prescription for Depression with a Focus on Nature Exposure and Screen Time: A Narrative Review.International journal of environmental research and public health · 2022Review
- Microglial/Macrophage polarization and function in brain injury and repair after stroke.CNS neuroscience & therapeutics · 2021Review
- Lifestyle behaviours during the COVID-19 - time to connect.Acta psychiatrica Scandinavica · 2020Article
- Spaceship Earth Revisited: The Co-Benefits of Overcoming Biological Extinction of Experience at the Level of Person, Place and Planet.International journal of environmental research and public health · 2020Article
- The importance of the exposome and allostatic load in the planetary health paradigm.Journal of physiological anthropology · 2018Review
- Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective.International journal of environmental research and public health · 2016Article
- The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health.Current environmental health reports · 2016Review
- The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Review
- Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku.Journal of physiological anthropology · 2016Article
- Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response.Frontiers in immunology · 2016Review
- Dysbiotic drift: mental health, environmental grey space, and microbiota.Journal of physiological anthropology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Famed microbiologist René J. Dubos (1901-1982) was an early pioneer in the developmental origins of health and disease (DOHaD) construct. In the 1960s, he conducted groundbreaking research concerning the ways in which early-life experience with nutrition, microbiota, stress, and other environmental variables could influence later-life health outcomes. He recognized the co-evolutionary relationship between microbiota and the human host. Almost 2 decades before the hygiene hypothesis, he suggested that children in developed nations were becoming too sanitized (vs. our ancestral past) and that scientists should determine whether the childhood environment should be "dirtied up in a controlled manner." He also argued that oft-celebrated growth chart increases via changes in the global food supply and dietary patterns should not be equated to quality of life and mental health. Here in the second part of our review, we reflect the words of Dubos off contemporary research findings in the areas of diet, the gut-brain-axis (microbiota and anxiety and depression) and microbial ecology. Finally, we argue, as Dubos did 40 years ago, that researchers should more closely examine the relevancy of silo-sequestered, reductionist findings in the larger picture of human quality of life. In the context of global climate change and the epidemiological transition, an allergy epidemic and psychosocial stress, our review suggests that discussions of natural environments, urbanization, biodiversity, microbiota, nutrition, and mental health, are often one in the same.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.