ArticleArthritis research & therapy2015
Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04012294 (Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Allopurinol on Inflammatory Markers and Morphostructural Changes Evidenced by Musculoskeletal Ultrasound in Individuals With Asymptomatic Hyperuricemia. A Proof of Concept
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal-related arthropathies.Animal models and experimental medicine · 2025Pooled it
- Gouty arthritis animal models: limitations, challenges, and optimization strategies.Frontiers in veterinary science · 2026Article
- MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin EStem cell research & therapy · 2025Article
- New animal model of chronic gout reproduces pathological features of the disease in humans.RMD open · 2023Article
- MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction.Frontiers in immunology · 2023Article
- Anti-Inflammatory and Hypouricemic Effect of Bioactive Compounds: Molecular Evidence and Potential Application in the Management of Gout.Current issues in molecular biology · 2022Review
- Article
- Transcriptomic analysis of the anti-inflammatory effect ofFrontiers in pharmacology · 2022Article
- Case Report: Articular Gout in Four Dogs and One Cat.Frontiers in veterinary science · 2022Article
- A novel parameter derived from post-processing procedure of dual energy CT for identification of gout.Scientific reports · 2021Article
- Effects of Stephania hainanensis alkaloids on MSU-induced acute gouty arthritis in mice.BMC complementary medicine and therapies · 2021Article
- Active Flavonoids FromFrontiers in pharmacology · 2021Article
- Neutrophil-lymphocyte ratio acts as a novel diagnostic biomarker for kidney stone prevalence and number of stones passed.Translational andrology and urology · 2021Article
- Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia.Journal of immunology research · 2021Article
- Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.BioMed research international · 2021Article
- Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography.World journal of radiology · 2020Article
- Etoricoxib prevents progression of osteolysis in repeated intra-articular monosodium urate-induced gouty arthritis in rats.Journal of advanced research · 2020Article
- Better understanding of acute gouty attack using CT perfusion in a rabbit model.European radiology · 2019Article
- Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound fromInternational journal of molecular sciences · 2018Article
- Value of ultrasonography in the diagnosis of gout in patients presenting with acute arthritis.Skeletal radiology · 2017Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
introductionGout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in the joints and soft tissues that can produce acute or chronic arthritis. Several animal models of crystal-induced inflammation have been proposed that involve direct injection of MSU-crystals into different anatomical structures; however, only a few of these models reflect a true diarthrodial joint microenvironment in which an acute gouty attack takes place. The aim of this study was to assess the inflammatory and structural joint changes in a rabbit model of acute gout attack by ultrasound (US), synovial fluid (SF) and histopathological analyses.
methodsUnder US guidance, 42 rabbit knees were randomly injected with a suspension of 50 mg/ml of either MSU or allopurinol synthetic crystals. The control group received intra-articular vehicle of phosphate-buffered saline (PBS). US evaluation, SF and histopathological analyses were performed at days 1, 3, and 7.
resultsA total of 21 rabbit knees were assigned to the control group, 12 to the MSU-crystals group, and 9 to the allopurinol crystals group. By US, the MSU crystals group displayed the double contour sign and bright stippled aggregates in 67% and 75% of joints, respectively. Neither control knees nor allopurinol crystals group displayed these US signs. Power Doppler (PD) signal was moderate to intense in the MSU-crystals group and greater than both the allopurinol crystal and control groups at day 1 (P<0.001) and 3 (P<0.05), with its practical disappearance by day 7. SF leukocyte count was 40,312±6,369 cells/mm3 in the MSU-crystals group, higher than in controls (P=0.004) and allopurinol crystal group (P=0.006). At day 7, SF leukocyte count decreased in both MSU and allopurinol crystal groups reaching the non-inflammatory range. Histologically, at day 3 intense synovial polymorphonuclear cells infiltration and MSU aggregates were identified.
conclusionThe rabbit model of MSU crystal-induced acute arthritis efficiently reproduces the inflammatory, US, SF and histopathological changes of the human acute gouty attack.
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