ArticleRadiation oncology (London, England)2015
Evaluating organ delineation, dose calculation and daily localization in an open-MRI simulation workflow for prostate cancer patients.
Article in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Converting from CT- to MRI-only-based target definition in radiotherapy of localized prostate cancer: A comparison between two modalities.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015Trial
- The dosimetric impacts of ct-based deep learning autocontouring algorithm for prostate cancer radiotherapy planning dosimetric accuracy of DirectORGANS.BMC urology · 2025Article
- First-in-Men Online Adaptive Robotic Stereotactic Body Radiation Therapy: Toward Ultrahypofractionation for High-Risk Prostate Cancer Patients.Advances in radiation oncology · 2025Article
- MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study.Scientific reports · 2024Article
- Cone beam computed tomography image guidance within a magnetic resonance imaging-only planning workflow.Physics and imaging in radiation oncology · 2023Article
- History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy.Journal of clinical medicine · 2022Review
- Improving the clinical workflow of a MR-Linac by dosimetric evaluation of synthetic CT.Frontiers in oncology · 2022Article
- Task group 284 report: magnetic resonance imaging simulation in radiotherapy: considerations for clinical implementation, optimization, and quality assurance.Medical physics · 2021Article
- Patient position verification in magnetic-resonance imaging only radiotherapy of anal and rectal cancers.Physics and imaging in radiation oncology · 2021Article
- Review
- The accuracy of Magnetic Resonance - Cone Beam Computed Tomography soft-tissue matching for prostate radiotherapy.Physics and imaging in radiation oncology · 2019Article
- Feasibility of magnetic resonance imaging-only rectum radiotherapy with a commercial synthetic computed tomography generation solution.Physics and imaging in radiation oncology · 2018Article
- Image-guided radiotherapy for prostate cancer.Translational andrology and urology · 2018Review
- MRI-only treatment planning: benefits and challenges.Physics in medicine and biology · 2018Review
- The future of image-guided radiotherapy will be MR guided.The British journal of radiology · 2017Review
- Initial clinical experience with a radiation oncology dedicated open 1.0T MR-simulation.Journal of applied clinical medical physics · 2015Article
- Dose evaluation of MRI-based synthetic CT generated using a machine learning method for prostate cancer radiotherapy.Medical dosimetry : official journal of the American Association of Medical DosimetristsArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study describes initial testing and evaluation of a vertical-field open Magnetic Resonance Imaging (MRI) scanner for the purpose of simulation in radiation therapy for prostate cancer. We have evaluated the clinical workflow of using open MRI as a sole modality for simulation and planning. Relevant results related to MRI alignment (vs. CT) reference dataset with Cone-Beam CT (CBCT) for daily localization are presented.
methodsTen patients participated in an IRB approved study utilizing MRI along with CT simulation with the intent of evaluating the MRI-simulation process. Differences in prostate gland volume, seminal vesicles, and penile bulb were assessed with MRI and compared to CT. To evaluate dose calculation accuracy, bulk-density-assignments were mapped onto respective MRI datasets and treated IMRT plans were re-calculated. For image localization purposes, 400 CBCTs were re-evaluated with MRI as the reference dataset and daily shifts compared against CBCT-to-CT registration. Planning margins based on MRI/CBCT shifts were computed using the van Herk formalism.
resultsSignificant organ contour differences were noted between MRI and CT. Prostate volumes were on average 39.7% (p = 0.002) larger on CT than MRI. No significant difference was found in seminal vesicle volumes (p = 0.454). Penile bulb volumes were 61.1% higher on CT, without statistical significance (p = 0.074). MRI-based dose calculations with assigned bulk densities produced agreement within 1% with heterogeneity corrected CT calculations. The differences in shift positions for the cohort between CBCT-to-CT registration and CBCT-to-MRI registration are -0.15 ± 0.25 cm (anterior-posterior), 0.05 ± 0.19 cm (superior-inferior), and -0.01 ± 0.14 cm (left-right).
conclusionsThis study confirms the potential of using an open-field MRI scanner as primary imaging modality for prostate cancer treatment planning simulation, dose calculations and daily image localization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.