ArticleArthritis research & therapy2015
Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye.The ocular surface · 2026Article
- Interferon-γ elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells.Cell death discovery · 2023Article
- IFN-γ Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2/STAT1 Pathway in Dry Eye.Investigative ophthalmology & visual science · 2023Article
- Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model.Investigative ophthalmology & visual science · 2023Article
- Transgenic dry eye mouse models: powerful tools to study dry eye disease.International journal of ophthalmology · 2022Review
- The Clinical and Immunological Activity Depending on the Presence of Interferon γ in Primary Sjögren's Syndrome-A Pilot Study.Journal of clinical medicine · 2021Article
- Secreted factors from dental pulp stem cells improve Sjögren's syndrome via regulatory T cell-mediated immunosuppression.Stem cell research & therapy · 2021Article
- Dental pulp-derived stem cell-conditioned media attenuates secondary Sjögren's syndrome via suppression of inflammatory cytokines in the submandibular glands.Regenerative therapy · 2021Article
- Modulation of Oxidative Stress and Inflammation in the Aged Lacrimal Gland.The American journal of pathology · 2021Article
- Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells.Mucosal immunology · 2019Article
- Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome.International journal of molecular sciences · 2018Article
- Interferons and Dry Eye in Sjögren's Syndrome.International journal of molecular sciences · 2018Review
- Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2018Article
- Protective role of commensal bacteria in Sjögren Syndrome.Journal of autoimmunity · 2018Article
- Sleep deprivation disrupts the lacrimal system and induces dry eye disease.Experimental & molecular medicine · 2018Article
- Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice.International journal of molecular sciences · 2018Article
- Comparison of femtosecond laser-assisted corneal intrastromal xenotransplantation and the allotransplantation in rhesus monkeys.BMC ophthalmology · 2017Article
- The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research.Ophthalmology · 2017Review
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren's syndrome.Scientific reports · 2016Article
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7 authors at 1 institution in 1 country.
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Abstract
introductionThe lacrimal gland (LG) of the CD25-/- model of Sjögren's syndrome (SS) has high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific contribution of these cytokines to the onset and severity of dacryoadenitis in the CD25-/- mice has not been evaluated.
methodsCD25-/-IL-17A-/-, CD25-/-IL-17-/-IFN-γ-/- and CD25-/-IFN-γ-/- were used at 4, 8, 12, 16 weeks (W). Total lymphocytic infiltration was evaluated by histology and characterized by flow cytometry. Epidermal growth factor (EGF) concentration was measured in tears. Immunofluorescent staining evaluated expression of IFN-γ receptor (IFN-γR) and apoptosis. Real-time PCR evaluated inflammatory and T cell-related cytokines expression in LG. Caspase-3, -8, -9 activities was assayed in LG lysates. T helper cytokines were measured in serum by Luminex assay.
resultsThe greatest total LG infiltration at 8 W was seen in CD25-/-IL-17A-/- (95%), followed by CD25-/- (71%) and IL-17-/- (12%). Tear EGF concentration was in normal range in CD25-/- at 4 W and in very low levels in both CD25-/- and CD25-/-IL-17A-/-. CD25-/- had high levels of inflammatory cytokines transcripts in LG compared to IL-17-/- mice; however, CD25-/-IL-17A-/- had even higher IL-1β, IFN-γR, caspase-3, -8, -9 mRNA levels, greater immunoreactivity to IFN-γR in LG acini, greater number of apoptotic+ cells and greater caspases activities in the LG at 8 W. CD25-/-IL-17A-/- had lower IL-13 concentration and lower IL-13/IFN-γ ratio compared to CD25-/- in serum. CD25-/-IFN-γ-/- had lower number of apoptotic+ cells and decreased caspase-3 expression in LG. CD25-/-IL-17-/-IFN-γ-/- had lower total lymphocytic cell infiltration at 8 W (48%), CD4+T cell infiltration and expression of IFN-γR and apoptotic+ cells in the LG and increased tear EGF concentration in tears.
conclusionsIFN-γ is critical for LG destruction and secretory dysfunction in the CD25-/- model of SS. Altered balance between IFN-γ and IL-13 in the CD25-/-IL-17A-/- mice accelerates LG destruction by increasing glandular apoptosis and facilitating apoptosis through increased expression of IFN-γR by glandular epithelium and activation of caspases. Targeting both IFN-γ and IL-17 may be beneficial for treating the LG inflammation in SS.
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