ArticleNeural development2015
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Article in Neural development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Communications biology · 2026Article
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Research square · 2025Article
- Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos.Science (New York, N.Y.) · 2025Article
- The Principle of Cortical Development and Evolution.Neuroscience bulletin · 2025Review
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- ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Fgf8Neuroscience bulletin · 2023Article
- Basal forebrain cholinergic signalling: development, connectivity and roles in cognition.Nature reviews. Neuroscience · 2023Review
- Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids.Molecular psychiatry · 2022Article
- Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- A role for sustained MAPK activity in the mouse ventral telencephalon.Developmental biology · 2021Article
- Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.Development (Cambridge, England) · 2021Article
- The mouse dorsal raphe nucleus as understood by temporal Fgf8 lineage analysis.The Journal of comparative neurology · 2021Article
- Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.The Journal of comparative neurology · 2019Article
- Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells.Frontiers in physiology · 2019Review
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3 authors.
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Abstract
backgroundThe rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8(CreER) and Fgf17(CreER) mice and used them to analyze the lineages of Fgf8- versus Fgf17-expressing RPC cells.
resultsBoth lineages contributed to medial structures of the rostroventral telencephalon structures including the septum and medial prefrontral cortex. In addition, RPC-derived progenitors were observed in other regions of the early telencephalic neuroepithelium and generated neurons in the olfactory bulb, neocortex, and basal ganglia. Surprisingly, Fgf8(+) RPC progenitors generated the majority of basal ganglia cholinergic neurons. Compared to the Fgf8 lineage, the Fgf17 lineage was more restricted in its early dispersion and its contributions to the telencephalon. Mutant studies suggested that Fgf8 and Fgf17 restrict spread of RPC progenitor subpopulations.
conclusionsWe identified the RPC as an important source of progenitors that contribute broadly to the telencephalon and found that two molecularly distinct progenitor subtypes in the RPC make different contributions to the developing forebrain.
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