ReviewBMC research notes2015
Kounis syndrome secondary to amoxicillin/clavulanic acid administration: a case report and review of literature.
Review in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 39 citations in OpenAlex.
- Case Report: An unusual case of cardiac anaphylaxis in the maintenance phase ofFrontiers in allergy · 2025Article
- Kounis Syndrome: Review of Clinical Cases.Cardiovascular & hematological disorders drug targets · 2024Review
- Clinical features, diagnosis and management of amoxicillin-induced Kounis syndrome.Frontiers in pharmacology · 2022Article
- Kounis Syndrome Secondary to Medicine-Induced Hypersensitivity.Case reports in medicine · 2021Article
- Kounis Syndrome Induced by Anisodamine: A Case Report.International journal of general medicine · 2020Article
- Vancomycin-induced coronary artery spasm: a case of Kounis syndrome.BMJ case reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKounis syndrome is the concurrence of acute coronary syndromes with mast cells activation induced by hypersensitivity and anaphylactoid insults and is increasingly encountered in clinical practice. The main pathophysiological mechanism is vasospasm of the epicardial coronary arteries due to increased inflammatory mediators that are released during a hypersensitivity reaction. CASE PRESENTATION: A 74-year -old Sinhalese man with diabetes mellitus was admitted with four day history of high fever with chills and rigors. His urine analysis and blood investigations revealed evidence of urinary tract infection. After excluding allergic conditions, he was given amoxicillin/clavulanic acid intravenously. About 20 minutes after the first dose he felt severe itching of body, nausea , dizziness and sever retrosternal chest pain. Urgent electrocardiogram was taken and it showed widespread ST segment elevations. He was treated for anaphylactic shock as well as acute coronary syndrome and was able to be discharged within a few days.
conclusionThis case highlights the occurrence of acute coronary syndrome following drug induced anaphylaxis. Acute coronary syndrome of this nature may be completely atypical and overlooked. Kounis syndrome should be borne in mind in the event of anaphylactic episode wherein the electrocardiogram becomes essential.
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