Evidence map›Paper›PMID 25888931›Full record

SynthesisSubstance abuse treatment, prevention, and policy2015

Polypharmacy among anabolic-androgenic steroid users: a descriptive metasynthesis.

Dominic Sagoe, Jim McVeigh, Astrid Bjørnebekk, Marie-Stella Essilfie, Cecilie Schou Andreassen, Ståle Pallesen

Abstract readSystematic Review
In one paragraph

Synthesis in Substance abuse treatment, prevention, and policy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dominic SagoeDepartment of Psychosocial Science, University of Bergen, Christiesgate 12, 5015, Bergen, Norway. dominic.sagoe@psysp.uib.no.
Jim McVeighCentre for Public Health, Liverpool John Moores University, 15-21 Webster Street, Liverpool, L3 2ET, UK. j.mcveigh@ljmu.ac.uk.
Astrid BjørnebekkDepartment of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Kirkeveien 166, Ullevål, Norway. astrid.bjornebekk@psykologi.uio.no.
Marie-Stella EssilfieDepartments of Surgery and Paediatrics, La General Hospital, PMB, Accra, Ghana. Essilfie@gmail.com.
Cecilie Schou AndreassenDepartment of Psychosocial Science, University of Bergen, Christiesgate 12, 5015, Bergen, Norway. cecilie.andreassen@psych.uib.no.
Ståle PallesenDepartment of Psychosocial Science, University of Bergen, Christiesgate 12, 5015, Bergen, Norway. staale.pallesen@psysp.uib.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs far as we are aware, no previous systematic review and synthesis of the qualitative/descriptive literature on polypharmacy in anabolic-androgenic steroid(s) (AAS) users has been published.

methodWe systematically reviewed and synthesized qualitative/descriptive literature gathered from searches in electronic databases and by inspecting reference lists of relevant literature to investigate AAS users' polypharmacy. We adhered to the recommendations of the UK Economic and Social Research Council's qualitative research synthesis manual and the PRISMA guidelines.

resultsA total of 50 studies published between 1985 and 2014 were included in the analysis. Studies originated from 10 countries although most originated from United States (n=22), followed by Sweden (n=7), England only (n=5), and the United Kingdom (n=4). It was evident that prior to their debut, AAS users often used other licit and illicit substances. The main ancillary/supplementary substances used were alcohol, and cannabis/cannabinoids followed by cocaine, growth hormone, and human chorionic gonadotropin (hCG), amphetamine/meth, clenbuterol, ephedra/ephedrine, insulin, and thyroxine. Other popular substance classes were analgesics/opioids, dietary/nutritional supplements, and diuretics. Our classification of the various substances used by AAS users resulted in 13 main groups. These non-AAS substances were used mainly to enhance the effects of AAS, combat the side effects of AAS, and for recreational or relaxation purposes, as well as sexual enhancement.

conclusionsOur findings corroborate previous suggestions of associations between AAS use and the use of other licit and illicit substances. Efforts must be intensified to combat the debilitating effects of AAS-associated polypharmacy.

Indexed as

Drug UsersPolypharmacySelf MedicationAnabolic AgentsAndrogensHumansAnabolic AgentsAndrogens

Identifiers

PMID25888931
PMCPMC4377045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.