ArticleMalaria journal2015
Genetic diversity of Plasmodium vivax population before elimination of malaria in Hainan Province, China.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Genetic diversity of theParasite epidemiology and control · 2024Article
- Low Genetic Diversity ofTropical medicine and infectious disease · 2024Article
- Genetic Diversity ofTropical medicine and infectious disease · 2023Article
- Geographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome.Malaria journal · 2023Article
- Distinct Allelic Diversity ofJournal of tropical medicine · 2023Article
- PvMSP-3α and PvMSP-3β genotyping reveals higher genetic diversity in Plasmodium vivax parasites from migrant workers than residents at the China-Myanmar border.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Article
- Prevalence of antifolate drug resistance markers in Plasmodium vivax in China.Frontiers of medicine · 2022Article
- Temporal Changes in the Genetic Diversity ofPathogens (Basel, Switzerland) · 2021Article
- An epidemiological survey of epilepsy in tropical rural areas of China.Epilepsia open · 2021Article
- Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka.Malaria journal · 2020Article
- Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax.Malaria journal · 2020Article
- Insights into the molecular diversity of Plasmodium vivax merozoite surface protein-3γ (pvmsp3γ), a polymorphic member in the msp3 multi-gene family.Scientific reports · 2020Article
- Changing pattern of the genetic diversities of Plasmodium falciparum merozoite surface protein-1 and merozoite surface protein-2 in Myanmar isolates.Malaria journal · 2019Article
- Evaluation of Plasmodium vivax isolates in Thailand using polymorphic markers Plasmodium merozoite surface protein (PvMSP) 1 and PvMSP3.Parasitology research · 2018Article
- Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China.Malaria journal · 2018Article
- Genetic diversity of Plasmodium Vivax revealed by the merozoite surface protein-1 icb5-6 fragment.Infectious diseases of poverty · 2017Article
- Higher Complexity of Infection and Genetic Diversity ofThe American journal of tropical medicine and hygiene · 2017Article
- Malaria control and prevention towards elimination: data from an eleven-year surveillance in Shandong Province, China.Malaria journal · 2017Article
- Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent.Malaria journal · 2016Article
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7 authors.
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Abstract
backgroundHainan Province is one of the most severe endemic regions with high transmission of Plasmodium falciparum and Plasmodium vivax in China. However, the incidence of P. falciparum and P. vivax has dropped dramatically since 2007 and a national elimination malaria programme (NEMP) was launched after 2010. To better understand the genetic information on P. vivax population before elimination of malaria in Hainan Province, the extent of genetic diversity of P. vivax isolates in Hainan Province was investigated using four polymorphic genetic markers, including P. vivax merozoite surface proteins 1, 3α, and 3β (pvmsp-1, pvmsp-3α, and pvmsp-3β) and circumsporozoite protein (pvcsp).
methodsIsolates of P. vivax (n = 27) from Hainan Province were collected from 2009 to 2010 and pvmsp-1 and pvcsp were analysed by DNA sequencing, respectively. Using polymerase chain reaction-restriction fragment length polymorphism were analysed in pvmsp-3α, and pvmsp-3β.
resultsThe DNA sequencing analysis on pvmsp1 revealed that there were three allele types: Salvador-1 (Sal-1), Belem and recombinant (R) types. Among them, Sal-1 type was a dominant strain with eight variant subtypes (88.9%), whereas R- (3.7%) and Belem-type strains (7.4%) had one variant subtypes, respectively. All the isolates carried pvcsp with VK210 type accounting for 85.2% (23/27 isolates) and VK247 type accounting for 14.8% (4/27). Only type A and type B alleles were successfully amplified in pvmsp-3α gene, and a high level of polymorphism was observed in pvmsp-3α. Considering pvmsp-3β gene, type A was the predominant type in 17 isolates (63%), whereas type B was dominant in only ten isolates (37%).
conclusionThe present data indicate that there was high degree of genetic diversity among P. vivax population in Hainan Province of China during the pre-elimination stage of malaria, with 26 unique haplotypes observed among 27 samples.
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