Evidence map›Paper›PMID 25888881›Full record

ArticleBehavioral and brain functions : BBF2015

Neurochemical, structural and neurobehavioral evidence of neuronal protection by whey proteins in diabetic albino mice.

Jamaan Ajarem, Ahmed A Allam, Hossam Ebaid, Saleh N Maodaa, Sanad M Al-Sobeai, Ahmed M Rady, Ali Metwalli, Naif G Altoom, Khaled Elfakki Ibrahim, Mohammad I Sabri

Open access · goldAbstract read
In one paragraph

Article in Behavioral and brain functions : BBF, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jamaan AjaremZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. jajarem@ksu.edu.sa.
Ahmed A AllamZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aallam@ksu.edu.sa.
Hossam EbaidZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. hossamebaid@yahoo.com.
Saleh N MaodaaZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. maodaa_28@yahoo.com.
Sanad M Al-SobeaiShaqra University Sajir College of Arts & Science, Shaqra, Saudi Arabia. sanadm555@gmail.com.
Ahmed M RadyZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. rady_gad1983@yahoo.com.
Ali MetwalliDepartment of Food Science, College of Agriculture and Food Science, King Saud University, Riyadh, Saudi Arabia. ametwalli@ksu.edu.sa.
Naif G AltoomZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. naifaltoom@hotmail.com.
Khaled Elfakki IbrahimZoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. kibrahim@ksu.edu.sa.
Mohammad I SabriOregon Health & Science University, Portland, OR, USA. sabri@ohsu.edu.
King Saud University · SAOregon Health & Science University · USShaqra University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes Mellitus (DM) is associated with pathological changes in the central nervous system (CNS) and alterations in oxidative stress. The aim of this study was to determine whether dietary supplement with whey protein (WP) could improve neurobehavior, oxidative stress and neuronal structure in the CNS.

methodsAnimals were distributed in three groups, a control group (N), a diabetic mellitus group (DM) and a DM group orally supplemented with WP (WP).

resultsThe DM group of animals receiving WP had reduced blood glucose, significantly decreased free radical Diphenyl-picrylhydrazyl (DPPH) and lower lipid peroxidation in brain tissue. The WP group of animals showed improvement in balancing, coordination and fore-limb strength, oxidative stress and neuronal structure.

conclusionThe results of this study show that dietary supplementation with WP reduced oxidative stress, protected CNS neurons and improved the neurobehavior of diabetic mice.

Indexed as

AnimalsBehavior, AnimalBiphenyl CompoundsBlood GlucoseBrainBrain ChemistryCamelusDiabetes Mellitus, ExperimentalHand StrengthHumansLipid PeroxidationMiceMotor ActivityNeuroprotective AgentsOxidation-ReductionPicrates1,1-diphenyl-2-picrylhydrazylBiphenyl CompoundsBlood GlucoseNeuroprotective AgentsPicratesWhey Proteins

Identifiers

PMID25888881
PMCPMC4331294
OpenAlexW2164028855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.