ArticleVirology journal2015
Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar.
Article in Virology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coronavirus sampling and surveillance in bats from 1996-2019: a systematic review and meta-analysis.Nature microbiology · 2023Pooled it
- Co-speciation and host-switching drives diversity of picornaviruses and sapoviruses in Malagasy fruit bats.Scientific reports · 2026Article
- Predicting current and future distributions of Malagasy bats: Implications for management of coronavirus spillover.One health (Amsterdam, Netherlands) · 2025Article
- Clade C MERS-CoV camel strains vary in protease utilization during viral entry.bioRxiv : the preprint server for biology · 2025Article
- Detection and genetic characterization of alphacoronaviruses in co-roosting bat species, southeastern Kenya.PLoS neglected tropical diseases · 2025Article
- Diversity and seasonality of ectoparasite burden on two species of Madagascar fruit bat, Eidolon dupreanum and Rousettus madagascariensis.Parasites & vectors · 2025Article
- Diversity and seasonality of ectoparasite burden on two species of Madagascar fruit bat,bioRxiv : the preprint server for biology · 2025Article
- Genomic characterization of novel bat kobuviruses in Madagascar: Implications for viral evolution and zoonotic risk.PloS one · 2025Article
- Increased Susceptibility ofViruses · 2024Article
- Reproduction, seasonal morphology, and juvenile growth in three Malagasy fruit bats.Journal of mammalogy · 2022Article
- Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations.Viruses · 2022Article
- Longitudinal Survey of Coronavirus Circulation and Diversity in Insectivorous Bat Colonies in Zimbabwe.Viruses · 2022Article
- Full GenomeFrontiers in public health · 2022Article
- Wildlife in Cameroon harbor diverse coronaviruses, including many closely related to human coronavirus 229E.Virus evolution · 2022Article
- Investigation of astrovirus, coronavirus and paramyxovirus co-infections in bats in the western Indian Ocean.Virology journal · 2021Article
- Overview of Bat and Wildlife Coronavirus Surveillance in Africa: A Framework for Global Investigations.Viruses · 2021Review
- Coronavirus surveillance in wildlife from two Congo basin countries detects RNA of multiple species circulating in bats and rodents.PloS one · 2021Article
- Analysis of partial sequences of the RNA-dependent RNA polymerase gene as a tool for genus and subgenus classification of coronaviruses.The Journal of general virology · 2020Article
- Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa.Viruses · 2020Article
- Bat coronavirus phylogeography in the Western Indian Ocean.Scientific reports · 2020Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island's chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats.
methodsFrugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens.
resultsFrom 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from Pteropus rufus and one from Eidolon dupreanum, giving an overall prevalence of 4.5%. Phylogenetic analysis revealed that the Malagasy strains belong to the genus Betacoronavirus but form three distinct clusters, which seem to represent previously undescribed genetic lineages.
conclusionsOur findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.
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