ArticleParasites & vectors2015
Vector competence of the Aedes aegypti population from Santiago Island, Cape Verde, to different serotypes of dengue virus.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 43 citations in OpenAlex.
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- Dengue Infection Susceptibility of FiveViruses · 2021Article
- Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa.PLoS neglected tropical diseases · 2021Article
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- Aedes aegypti continuously exposed to Bacillus thuringiensis svar. israelensis does not exhibit changes in life traits but displays increased susceptibility for Zika virus.Parasites & vectors · 2021Article
- Effect of Serotype and Strain Diversity on Dengue Virus Replication in Australian Mosquito Vectors.Pathogens (Basel, Switzerland) · 2020Article
- The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa.PLoS neglected tropical diseases · 2020Article
- Abundance and Updated Distribution ofInternational journal of environmental research and public health · 2020Article
- Globe-TrottingVector borne and zoonotic diseases (Larchmont, N.Y.) · 2020Review
- Susceptibility of mosquito vectors of the city of Praia, Cabo Verde, to Temephos and Bacillus thuringiensis var israelensis.PloS one · 2020Article
- Phylogeography and invasion history ofEvolutionary applications · 2019Article
- Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia.Annals of global health · 2019Article
- Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa.PLoS neglected tropical diseases · 2019Article
- Aedes aegypti vector competence studies: A review.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Review
- Potential of Aedes aegypti populations in Madeira Island to transmit dengue and chikungunya viruses.Parasites & vectors · 2018Article
- Aedes Mosquitoes and Aedes-Borne Arboviruses in Africa: Current and Future Threats.International journal of environmental research and public health · 2018Review
- Circulation of DENV2 and DENV4 in Aedes aegypti (Diptera: Culicidae) mosquitoes from Praia, Santiago Island, Cabo Verde.Journal of insect science (Online) · 2017Article
- Peridomestic Aedes malayensis and Aedes albopictus are capable vectors of arboviruses in cities.PLoS neglected tropical diseases · 2017Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is an arboviral disease caused by dengue virus (DENV), whose main vectors are the mosquitoes Aedes aegypti and Aedes albopictus. A. aegypti is the only DENV vector in Cape Verde, an African country that suffered its first outbreak of dengue in 2009. However, little is known about the variation in the level of vector competence of this mosquito population to the different DENV serotypes. This study aimed to evaluate the vector competence of A. aegypti from the island of Santiago, Cape Verde, to four DENV serotypes and to detect DENV vertical transmission.
methodsMosquitoes were fed on blood containing DENV serotypes and were dissected at 7, 14 and 21 days post-infection (dpi) to detect the virus in the midgut, head and salivary glands (SG) using RT-PCR. Additionally, the number of copies of viral RNA present in the SG was determined by qRT-PCR. Furthermore, eggs were collected in the field and adult mosquitoes obtained were analyzed by RT-PCR and the platelia dengue NS1 antigen kit to detect transovarial transmission.
resultsHigh rates of SG infection were observed for DENV-2 and DENV-3 whereas for DENV-1, viral RNA was only detected in the midgut and head. DENV-4 did not spread to the head or SG, maintaining the infection only in the midgut. The number of viral RNA copies in the SG did not vary significantly between DENV-2 and DENV-3 or among the different periods of incubation and the various titers of DENV tested. With respect to DENV surveillance in mosquitoes obtained from the eggs collected in the field, no samples were positive.
conclusionAlthough no DENV positive samples were collected from the field in 2014, it is important to highlight that the A. aegypti population from Santiago Islands exhibited different degrees of susceptibility to DENV serotypes. This population showed a high vector competence for DENV-2 and DENV-3 strains and a low susceptibility to DENV-1 and DENV-4. Viral RNA copies in the SG remained constant for at least 21 dpi, which may enhance the vector capacity of A. aegypti and suggests the presence of a mechanism modulating virus replication in the SG.
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