ArticleParticle and fibre toxicology2015
Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes.
Article in Particle and fibre toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies.Environmental health and preventive medicine · 2020Pooled it
- Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence.International journal of public health · 2019Pooled it
- Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies.Particle and fibre toxicology · 2025Article
- The turbulent future brings a breath of fresh air.Nature communications · 2023Article
- Short-term exposure to ultrafine and fine particulate matter with multipollutant modelling on heart rate variability among seniors and children from the CorPuScula (coronary, pulmonary, sanguis) longitudinal study in Germany.Frontiers in epidemiology · 2023Article
- Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease.International journal of molecular sciences · 2022Review
- Perfluoroalkyl substances influence DNA methylation in school-age children highly exposed through drinking water contaminated from firefighting foam: a cohort study in Ronneby, Sweden.Environmental epigenetics · 2022Article
- Key Characteristics of Cardiovascular Toxicants.Environmental health perspectives · 2021Article
- Response of the Cardiac Autonomic Control to Exposure to Nanoparticles and Noise: A Cross-Sectional Study of Airport Ground Staff.International journal of environmental research and public health · 2021Article
- Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020Review
- STRATOS guidance document on measurement error and misclassification of variables in observational epidemiology: Part 1-Basic theory and simple methods of adjustment.Statistics in medicine · 2020Review
- The health effects of ultrafine particles.Experimental & molecular medicine · 2020Review
- Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany.Environmental health perspectives · 2020Article
- Effects of occupational exposure to dust on chest radiograph, pulmonary function, blood pressure and electrocardiogram among coal miners in an eastern province, China.BMC public health · 2019Article
- Healthy Air, Healthy Brains: Advancing Air Pollution Policy to Protect Children's Health.American journal of public health · 2019Article
- Acute Effects of Air Pollution and Noise from Road Traffic in a Panel of Young Healthy Adults.International journal of environmental research and public health · 2019Article
- Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma.Environment international · 2018Article
- Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.Environmental health perspectives · 2017Review
- Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome.Particle and fibre toxicology · 2017Article
- Ambient Air Quality Measurements from a Continuously Moving Mobile Platform: Estimation of Area-Wide, Fuel-Based, Mobile Source Emission Factors Using Absolute Principal Component Scores.Atmospheric environment (Oxford, England : 1994) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation.
methodsSixty-four individuals with type 2 diabetes and impaired glucose tolerance recorded ambulatory electrocardiograms over five to six hours on 191 occasions in a panel study in Augsburg, Germany. Personal exposure to particle number concentrations (PNC) was monitored for each individual on 5-minute basis concurrently and particulate matter with an aerodynamic diameter<2.5 μm (PM2.5) was acquired from a central monitoring site on an hourly basis.
resultsMore than 11,000 5-minute intervals were available for heart rate and measures of heart rate variability including SDNN (standard deviation of NN intervals). A concurrent decrease in 5-minute SDNN of -0.56% (95% confidence limits (CI): -1.02%; -0.09%) and a 5-minute delayed increase in heart rate of 0.23 % (95% CI: 0.11%; 0.36%) was observed with an increase in personal PNC of 16,000 per cm3 in additive mixed models. Models evaluating the association of concurrent 5-minute personal PNC and of 1-hour PM2.5 showed independent effects on SDNN.
conclusionThe data suggest that freshly emitted ultrafine particles and aged fine particulate matter are both associated with changes in cardiac function in individuals with type 2 diabetes and impaired glucose tolerance in urban areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.