Trial reportHealth and quality of life outcomes2015
Early intervention influences positively quality of life as reported by prematurely born children at age nine and their parents; a randomized clinical trial.
Trial report in Health and quality of life outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00222456 (Can Early Intervention Prevent Developmental Disturbances/Delays and Improve the Health of Children Born Prematurely), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Early Intervention Prevent Developmental Disturbances/Delays and Improve the Health of Children Born Prematurely
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Home visits following hospital discharge for families with preterm and low-birthweight infants.The Cochrane database of systematic reviews · 2026Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of early intervention programs for parents of preterm infants: a meta-review of systematic reviews.BMC pediatrics · 2018Pooled it
- Neurodevelopment after a strength-based intervention in children born extremely preterm: a randomised controlled trial.Pediatric research · 2026Article
- An Integrated Review of Transitional Care for Families of Pre-Term Infants.Healthcare (Basel, Switzerland) · 2024Review
- Perception and Educational Needs of Developmentally Supportive Care At-Home for Parents of Pre-Term Newborns.Healthcare (Basel, Switzerland) · 2023Article
- Early Intervention in Families with Preterm Infants: A Review of Findings from a Randomized Controlled Trial Following Children Up to 9 Years of Age.Children (Basel, Switzerland) · 2022Article
- Consequences of Prematurity on Cortisol Regulation and Adjustment Difficulties: A 9-Year Longitudinal Study.Children (Basel, Switzerland) · 2021Article
- Clinical relevance of activities meaningful to parents of preterm infants with very low birth weight: A focus group study.PloS one · 2018Article
- Scoping review of interventions to support families with preterm infants post-NICU discharge.Journal of pediatric nursingArticle
- Behavioral Health Service Utilization and Unmet Need After Traumatic Brain Injury in Childhood.Journal of developmental and behavioral pediatrics : JDBPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Tromsø Intervention Study on Preterms evaluates an early, sensitizing intervention given to parents of prematurely born children (birth-weight < 2000 g). The current study investigated the potential influence of the intervention on children's self-reported and parental proxy-reported quality of life (QoL) at children's age of nine.
methodsParticipants were randomized to either intervention (PI, n = 72) or preterm control (PC, n = 74) in the neonatal care unit, while healthy term-born infants were recruited to a term reference group (TR, n = 75). The intervention was a modified version of the Mother-Infant Transaction Program, and comprised eight one-hour sessions during the last week before discharge and four home visits at 1, 2, 4 and 12 weeks post-discharge. The two control groups received care in accordance with written guidelines drawn up at the hospital. Participants and parents reported QoL independently on the Kinder Lebensqualität Fragebogen (KINDL) questionnaire. Differences between groups were analyzed by SPSS; Linear Mixed Models and parent-child agreement were analyzed and compared by intra-class correlations within each group.
resultsOn average, children in all groups reported high levels of well-being. The PI children reported better physical well-being than the PC children (p = 0.002). In all other aspects of QoL both the PI and the PC children reported at similar levels as the term reference group. PI parents reported better emotional wellbeing (p = 0.05) and a higher level of contentment in school (p = 0.003) compared with PC parents. Parent-child agreement was significantly weaker in the PI group than in the PC group on dimensions such as emotional well-being and relationships with friends (p < 0.05). PI parents reported QoL similar to parents of terms on all aspects except the subscale self-esteem, while PC parents generally reported moderately lower QoL than TR parents.
conclusionsThis early intervention appears to have generated long-lasting positive effects, improving perceived physical well-being among prematurely born children and parent's perception of these children's QoL in middle childhood.
trial registrationClinical Trials Gov NCT00222456 .
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