Evidence map›Paper›PMID 25888764›Full record

ArticleJournal of translational medicine2015

Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia.

Rabia Shabir Ahmad, Masood Sadiq Butt, M Tauseef Sultan, Zarina Mushtaq, Shakeel Ahmad, Saikat Dewanjee, Vincenzo De Feo, Muhammad Zia-Ul-Haq

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 75 citations in OpenAlex.

  1. Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019
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  18. Green tea and metabolic syndrome: A 10-year research update review.Iranian journal of basic medical sciences · 2021
    Review
  19. Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role ofEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  20. Anti-obesity effects of a mixed extract containingExperimental and therapeutic medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Rabia Shabir AhmadDepartment of Food Science, Nutrition and Home Economics, Govt College University Faisalabad, Faisalabad, Pakistan. rabiyaseen@yahoo.com.
Masood Sadiq ButtNational institute of Food Science and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan. drmsbutt@yahoo.com.
M Tauseef SultanDepartment of Food Science and Technology, Bahauddin Zakariya University, Multan, Pakistan. tauseefsultan@bzu.edu.pk.
Zarina MushtaqDepartment of Food Science, Nutrition and Home Economics, Govt College University Faisalabad, Faisalabad, Pakistan. zee_ft@hotmail.com.
Shakeel AhmadDepartment of Agronomy, Bahauddin Zakariya University, Multan, Pakistan. shakeel.agronomy@gmail.com.
Saikat DewanjeeAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India. s.dewanjee@yahoo.com.
Vincenzo De FeoDepartment of Pharmacy, University of Salerno, Fisciano, Salerno, 84084, Italy. defeo@unisa.it.
Muhammad Zia-Ul-HaqThe Patent Office, Karachi, Pakistan. ahirzia@gmail.com.
Bahauddin Zakariya University · PKUniversity of Faisalabad · PKJadavpur University · INUniversity of Agriculture Faisalabad · PKUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including obesity, hypercholesterolemia and diabetes. In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi-Men) against lifestyle related disorders.

methodsFunctional drinks (T2 and T3) were prepared by adding catechins and epigallocatechin gallate (EGCG) @ 550 mg/500 mL and compared with control (T1). These functional drinks were tested in experimental rats modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high cholesterol diet), trial-III (high sucrose diet), trial-IV (high cholesterol + high sucrose diet). Rats were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56 days rats were sacrificed and evaluated their serum lipid (cholesterol, LDL and HDL), glucose and insulin levels.

resultsResults for feed consumption by rats revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, cholesterol and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum glucose and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing EGCG reduced the trait better than catechins based functional drink.

conclusionsThe drinks supplemented with catechins and EGCG are effective against obesity, hypercholesterolemia and hyperglycemia.

Indexed as

AnimalsBlood GlucoseBody WeightCatechinDrinking BehaviorFeeding BehaviorHypercholesterolemiaHyperglycemiaInsulinObesityProtective AgentsRats, Sprague-DawleyTeaBlood GlucoseCatechinInsulinProtective AgentsTea

Identifiers

PMID25888764
PMCPMC4351924
OpenAlexW2148026869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.