ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2016
Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
174 citing papers in PubMed, 7 syntheses or guidelines pooled it, 366 citations in OpenAlex.
- Psychiatric disorders after deep brain stimulation of the subthalamic nucleus in Parkinson's disease: a systematic review.Einstein (Sao Paulo, Brazil) · 2024Pooled it
- Is Deep Brain Stimulation an Effective Treatment for Psychostimulant Dependency? A Preclinical and Clinical Systematic Review.Neurochemical research · 2023Pooled it
- Deep brain stimulation in Lesch-Nyhan syndrome: a systematic review.Neurosurgical review · 2023Pooled it
- Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review.Neurosurgical review · 2021Pooled it
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Deep brain stimulation for dystonia.The Cochrane database of systematic reviews · 2019Pooled it
- Comparison Between Levodopa-Carbidopa Intestinal Gel Infusion and Subthalamic Nucleus Deep-Brain Stimulation for Advanced Parkinson's Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Trial
- Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease.Clinical interventions in aging · 2019Trial
- Current Clinical Trials to Treat Anxiety Disorders in the Elderly: A Registry-Based Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Deep Brain Stimulation Induces Antidepressant Effects by Restoring High-Fidelity Communication in the BNST-NAc Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuromodulatory Effects of Substantia Nigra Pars Reticulata Deep Brain Stimulation (SNr-DBS) in the 6-Hydroxydopamine Rat Model of Parkinson's Disease.Medicina (Kaunas, Lithuania) · 2026Article
- Bifurcation of neural firing patterns driven by potassium dynamics and neuron-electrode geometry during high-frequency stimulation.PLoS computational biology · 2026Article
- Neuroscientific therapies for subjective tinnitus.Journal of Zhejiang University. Science. B · 2026Review
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Cerebellar deep brain stimulation rescues Purkinje cell mitochondrial density in a genetic mouse model of cerebellar ataxia.Brain research bulletin · 2026Article
- Neuromodulation of Working Memory: Mechanisms, Targets, and Behavioral Outcomes.Neuroscience insights · 2026Review
- Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice.PloS one · 2026Article
- Sense of agency and addiction.Frontiers in psychology · 2026Article
- Differential synaptic depression mediates the therapeutic effect of deep brain stimulation.Nature neuroscience · 2025Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson's disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.