ArticleLupus2015
Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE.
Article in Lupus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Subclinical ocular microvascular involvement in primary antiphospholipid syndrome and antiphospholipid antibody carriers.Lupus science & medicine · 2026Article
- Optic nerve head microcirculation on optical coherence tomography angiography is reduced in systemic lupus erythematosus and relates to nailfold videocapillaroscopy phenotypes: a cross-sectional case-control study.Clinical rheumatology · 2026Article
- A deep learning system for detecting systemic lupus erythematosus from retinal images.Cell reports. Medicine · 2025Article
- Application of SS-OCTA to evaluate the effects of long-term hydroxychloroquine treatment on retinal structure and microcirculation in patients with systemic lupus erythematosus.BMC ophthalmology · 2025Article
- Establishing normal interocular symmetry range for macular optical coherence tomography parameters in healthy children.Eye (London, England) · 2025Article
- Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography.Journal of ophthalmic inflammation and infection · 2025Article
- Belimumab-driven reductions in retinal microvascular density assessed by optical coherence tomography angiography: insights from systemic lupus erythematosus patients.Frontiers in immunology · 2025Article
- Ocular fundus changes and association with systemic conditions in systemic lupus erythematosus.Frontiers in immunology · 2024Review
- Quantitative evaluation of retinal and choroidal vascularity in systemic lupus erythematosus by SS-OCT/OCTA.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Assessment of peripapillary retinal nerve fiber layer thickness and vessel density in newly diagnosed SLE patients without ocular symptoms.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Article
- Subclinical retinopathy in systemic lupus erythematosus patients - optical coherence tomography study.Reumatologia · 2023Article
- Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus.Journal of clinical medicine · 2022Article
- An Evaluation of Choroidal and Retinal Nerve Fiber Layer Thicknesses Using SD-OCT in Children with Childhood IgA Vasculitis.Diagnostics (Basel, Switzerland) · 2022Article
- Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome.Frontiers in neurology · 2022Article
- Retinal thickness and microvascular alterations in the diagnosis of systemic lupus erythematosus: a new approach.Quantitative imaging in medicine and surgery · 2022Article
- Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions.Sensors (Basel, Switzerland) · 2021Article
- Optical Coherence Tomography Angiography as a New Tool for Evaluation of the Subclinical Retinal Involvement in Patients with Systemic Lupus Erythematosus-A Review.Journal of clinical medicine · 2021Review
- Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults.Scientific reports · 2021Article
- Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults.Translational vision science & technology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveDue to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE.
methodsRetinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLE patients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests.
resultsNPSLE patients did not differ significantly from non-NP SLE patients in retinal thickness or macular volume. However, SLE patients as a whole showed significant RNFL and macular thinning compared to controls. Scores on the Trail Making Test B, a test of complex attention, showed significant correlation to temporal superior and temporal inferior RNFL thickness.
conclusionOur results demonstrate RNFL thinning in SLE, and confirm the previous finding of high incidence of abnormal brain scans in SLE. These findings suggest that OCT measurements may be indicative of neurodegeneration in SLE and may be a useful biomarker for early cognitive impairment in SLE.
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